linkstream2 microblog

http://www.sciencemag.org/news/2016/03/alzheimer-s-may-be-caused-haywire-immune-system-eating-brain-connections

Alzheimer’s may be caused by haywire immune system eating brain connections Study targets new mechanism in fight against cognitive decline

Susceptibility of brain atrophy to TRIB3 in #Alzheimer’s disease, evidence from functional prioritization in imaging genetics
http://www.PNAS.org/content/115/12/3162.long Nice connection of developing phenotypes from #imaging, combined w. simple polygenic scores from genotypes

https://www.nature.com/articles/s41467-017-02577-y

Genome-Scale Signatures of Gene Interaction from #CompoundScreens Predict…Efficacy of Targeted Cancer Therapies
https://www.ScienceDirect.com/science/article/pii/S2405471218300097 How to find drug combos: Find expression response profiles associated w/ a drug target. A synergistic drug might change profiles similarly

#CryoEM structure of substrate-bound human telomerase holoenzyme https://www.Nature.com/articles/s41586-018-0062-x Quote: “2 flexibly RNA-tethered lobes: the catalytic core (w/ #TERT & conserved motifs of telomerase RNA) & an H/ACA RNP”

Fast, scalable prediction of deleterious #noncoding variants from functional & population genomic data
https://www.Nature.com/articles/ng.3810 LINSIGHT, by @ASiepel et al., combines DNAse & conservation information

Yi-Fei Huang, Brad Gulko & Adam Siepel
Nature Genetics 49, 618–624 (2017)
doi:10.1038/ng.3810
Published online:
13 March 2017

Interesting paper by alumnus Renqiang Min on “Video Generation from Text,” using a generative #MachineLearning model.
http://www.AAAI.org/GuideBook2018/16152-72279-GB.pdf (Press report by @SilverJacket: New algorithm can create movies from just a few snippets of text
http://www.ScienceMag.org/news/2018/02/new-algorithm-can-create-movies-just-few-snippets-text )

Video Generation from Text Yitong Li†∗, Martin Renqiang Min‡ , Dinghan Shen† , David Carlson† , Lawrence Carin† †

https://www.nature.com/articles/nature25980

A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex

Suijuan Zhong
, Shu Zhang
[…]
Xiaoqun Wang
Nature
doi:10.1038/nature25980

Received: 13 November 2017 Revised: 22 November 2017 Accepted: 29 November 2017 https://www.nature.com/articles/s41525-017-0040-5.pdf

Fast, scalable prediction of deleterious #noncoding variants from functional & population genomic data https://www.Nature.com/articles/ng.3810 LINSIGHT, by @ASiepel et al., combines DNAse & conservation information

Yi-Fei Huang, Brad Gulko & Adam Siepel

Nature Genetics 49, 618–624 (2017)
doi:10.1038/ng.3810
Published online:

13 March 2017