Posts Tagged ‘psychencode’

GWAS ATLAS resource

Saturday, August 24th, 2019

A global overview of pleiotropy and genetic architecture in complex traits

Kyoko Watanabe, Sven Stringer, Oleksandr Frei, Maša Umićević Mirkov, Christiaan de Leeuw, Tinca J. C. Polderman, Sophie van der Sluis, Ole A. Andreassen, Benjamin M. Neale & Danielle Posthuma

https://www.nature.com/articles/s41588-019-0481-0

Single Cell Resource for Mouse

Saturday, August 3rd, 2019

QT:{{”

Tabula Muris is a compendium of single cell transcriptome data from the model organism Mus musculus, containing nearly 100,000 cells from 20 organs and tissues. The data allow for direct and controlled comparison of gene expression in cell types shared between tissues, such as immune cells from distinct anatomical locations. They also allow for a comparison of two distinct technical approaches: “}}

https://tabula-muris.ds.czbiohub.org/

SHANK3 | Spectrum | Autism Research News

Saturday, July 20th, 2019

https://www.spectrumnews.org/wiki/shank3/

From Zhu et al. Science (’18)
QT:{{”
Further analysis revealed that the ASD-associated genes SHANK2 and SHANK3, which encode synaptic scaffolding proteins at the postsynaptic density of excitatory glutamatergic synapses, exhibited earlier expression in the macaque NCX and other brain regions relative to humans (Fig. 7B).
“}}

Evaluation of chromatin accessibility in prefrontal cortex of individuals with schizophrenia | Nature Communications

Sunday, April 7th, 2019

https://www.nature.com/articles/s41467-018-05379-y

The highly pleiotropic gene SLC39A8 as an opportunity to gain insight into the molecular pathogenesis of schizophrenia – Costas – 2018 – American Journal of Medical Genetics Part B: Neuropsychiatric Genetics – Wiley Online Library

Sunday, April 7th, 2019

https://onlinelibrary.wiley.com/doi/full/10.1002/ajmg.b.32545

assoc w. SCZ+Chron’s
protective to Parkinson’s

Genome-wide de novo risk score implicates promoter variation in autism spectrum disorder. – PubMed – NCBI

Sunday, April 7th, 2019

https://www.ncbi.nlm.nih.gov/pubmed/30545852
gsp

The highly pleiotropic gene SLC39A8 as an opportunity to gain insight into the molecular pathogenesis of schizophrenia – Costas – 2018 – American Journal of Medical Genetics Part B: Neuropsychiatric Genetics – Wiley Online Library

Sunday, April 7th, 2019

https://onlinelibrary.wiley.com/doi/full/10.1002/ajmg.b.32545

assoc w. SCZ+Chron’s
protective to Parkinson’s

Human Cell Atlas Method Development Community timeline

Sunday, April 7th, 2019

https://www.protocols.io/groups/hca

neuroDEVELOPMENTS: Neuroscience Research to Clinical Relevance

Monday, April 1st, 2019

https://mailchi.mp/add7f814b67d/neurodevelopments-720229
https://www.libd.org/neurodevelopments/

the Lieber’s neuroDEVELOPMENTS newsletter, which features the PsychENCODE paper

Final Article — American Scholar Magazine

Tuesday, March 12th, 2019

WORKS IN PROGRESS – SPRING 2019
Decoding DNA
On the hunt for the genetic roots of mental illnesses

By Marcus Banks | March 4, 2019

QT:[[”
The model, a form of artificial intelligence, aims to use abstract knowledge gained in the research lab to improve clinical treatments for real patients. The ultimate goal, says Gerstein, is to use the model to develop pharmaceutical treatments that reduce the impact of schizophrenia. Part of the challenge in developing drugs to treat the disease is the fact that it is not a one-size-fits-all condition. “]]

https://theamericanscholar.org/decoding-dna/#.XH7RRlNKiqA