Exonic Transcription Factor Binding Directs Codon Choice and Affects Protein Evolution

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We found that ~15% of human codons are dual-use codons (โ€œduonsโ€) that simultaneously specify both amino acids and TF recognition sites. Duons are highly conserved and have shaped protein evolution, and TF-imposed constraint appears to be a major driver of codon usage bias.
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http://www.sciencemag.org/content/342/6164/1325.summary
http://www.sciencemag.org/content/342/6164/1367.abstract

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One Response to “Exonic Transcription Factor Binding Directs Codon Choice and Affects Protein Evolution”

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