Posts Tagged ‘regulation’

Exonic Transcription Factor Binding Directs Codon Choice and Affects Protein Evolution

Sunday, December 15th, 2013

We found that ~15% of human codons are dual-use codons (“duons”) that simultaneously specify both amino acids and TF recognition sites. Duons are highly conserved and have shaped protein evolution, and TF-imposed constraint appears to be a major driver of codon usage bias.