linkstream2 microblog

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804872/

QT:[[”
Genome-wide association studies (GWAS) have enabled significant progress in the past 5 years in investigating genetic susceptibility to lung cancer. Large scale, multi-cohort GWAS of mainly Caucasian, smoking, populations have identified strong associations for lung cancer mapped to chromosomal regions 15q [nicotinic acetylcholine receptor (nAChR) subunits: CHRNA3, CHRNA5], 5p (TERT-CLPTM1L locus) and 6p (BAT3-MSH5). Some studies in Asian populations of smokers have found similar risk loci, whereas GWAS in never smoking Asian females have identified associations in other chromosomal regions, e.g., 3q (TP63), that are distinct from smoking-related lung cancer risk loci. GWAS of smoking behaviour have identified risk loci for smoking quantity at 15q (similar genes to lung cancer susceptibility: CHRNA3, CHRNA5) and 19q (CYP2A6).
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Good quote:

“Schopenhauer,” he says, “argued that the higher your tolerance for noise, the lower your intelligence.”

https://www.nytimes.com/2019/04/05/nyregion/gentrification-one-percent-manhattan.html

https://www.1843magazine.com/features/death-of-the-calorie

QT:[[”
This was pioneering stuff for the 1890s. Atwater eventually concluded that a gram of either carbohydrate or protein made an average of four calories of energy available to the body, and a gram of fat offered an average of 8.9 calories, a figure later rounded up to nine calories for convenience. We now know far more about the workings of the human body: Atwater was right that some of a meal’s potential energy was excreted, but had no idea that some was also used to digest the meal itself, and that the body expends different amounts of energy depending on the food. Yet more than a century after igniting the faeces of Wesleyan students, the numbers Atwater calculated for each macro­nutrient remain the standard for measuring the calories in any given food stuff. Those experiments were the basis of Salvador Camacho’s daily calorific arithmetic.
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QT:[[”

“A lot of things that take up mental energy, waste time, and rarely move you toward your goals can easily be eliminated if you apply the Eisenhower Principle. It’s a simple decision-making tool you can use right now. It’s meant to help you question whether an action is really necessary.

…

You can only benefit from the Eisenhower Method if you can commit yourself to making radical categorization of your daily tasks. This Method requires that you group your tasks and activities into four priorities.

Priority 1 tasks are both urgent and important.
Priority 2 tasks are important but not urgent.
Priority 3 tasks are urgent but not important.
Priority 4 tasks are neither urgent nor important”

The Eisenhower Method For Taking Action (How to Distinguish Between Urgent and Important Tasks)
https://medium.com/the-mission/the-eisenhower-method-for-taking-action-how-to-distinguish-between-urgent-and-important-tasks-895339a13dea via Instapaper

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liked particularly:

QT:[[”
3. Don’t go meta. Minimize concepts about concepts, like “approach, assumption, concept, condition, context, framework, issue, level, model, perspective, process, range, role, strategy, tendency,” and “variable.”

8. Old information at the beginning of the sentence, new information at the end.

10. Prose must cohere: readers must know how each sentence is related to the preceding one. If it’s not obvious, use “that is, for example, in general, on the other hand, nevertheless, as a result, because, nonetheless,” or “despite.”

12. Read it aloud.
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https://boingboing.net/2019/03/27/here-are-cognitive-scientist-s.html

QT:[[”

If you need the accuracy of a real person doing your transcribing but have only hours of turnaround time to spare, Rev could be a good option. It has the best editor tool (in fact, the same editor as the AI-based Trint) and the easiest upload process of any of the human services we tested. But although it was more accurate than any of the AI-based services we tried, it consistently returned the
hardest-to-read and most error-filled transcriptions (aside from the jargon transcription, on which it tied for the most accurate) while being the costliest of the services we tested. The Rev transcripts were still readable, but we think it’s worthwhile to wait a bit longer for the cheaper and more accurate GoTranscript service if you have the time.

Scribie took the longest of any tested service to return our transcripts, had the worst editor, had the slowest upload process, and sported the poorest user interface. When we submitted our audio sample of a speaker with a foreign accent, Scribie rejected it. A customer service representative stated that the file was too short and too complicated for the service to find someone willing to transcribe it; Scribie rejected a second, longer accented file too. If you need to submit an audio file only on occasion or have lots of clear audio files, Scribie could still be a good option—it’s the least expensive real-people service we tried, and it produced easy-to-read and accurate transcripts for us. But steer clear if you want to be sure your uploads are accepted reliably.”
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The Best Transcription Services
https://thewirecutter.com/reviews/best-transcription-services/

QT:[[”
“As he grew in his profession, Six came to feel he had a right to express himself on the family collection. A series of clashes with his father ensued, many of them about providing greater public access, which has always been a difficulty. Currently, tours of the
collection, which are by appointment only, are booked into next year. The picture that the younger Six sketched was of an inward-looking father who is trying to preserve a legacy by keeping the world at bay, who comes to realize over time that he also has to do battle with a gregarious and extroverted son who feels that the way to preserve that legacy is precisely by sharing it with the wider world. The battles left the younger Six progressively more exasperated: “I would cycle home after and think, Jesus, Dad, I’m trying to help you.””
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Rembrandt in the Blood: An Obsessive Aristocrat, Rediscovered Paintings and an Art-World Feud
https://www.nytimes.com/2019/02/27/magazine/rembrandt-jan-six.html

http://cebp.aacrjournals.org/content/27/4/363.long

QT:[[”
The first GWAS on lung cancer were reported in 2008. Three independent studies identified a susceptibility locus on chromosome 15q. Hung and colleagues (14) found two SNPs strongly associated with lung cancer on chromosome 15q25. Further genotyping in this region revealed many SNPs in tight linkage disequilibrium (LD) showing evidence of association. Six genes are located in this region including three nicotinic acetylcholine receptor subunits (CHRNA5, CHRNA3, and CHRNB4). Interestingly, no appreciable variation in the risk was found across smoking categories or histologic subtypes of lung cancer. In a second GWAS, a SNP within the CHRNA3gene was strongly associated with smoking quantity and nicotine dependence (15). The same SNP was also strongly associated with lung cancer. The results suggest that the variant on chromosome 15q25 confers risk of lung cancer through its effect on tobacco addiction.
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https://data.library.virginia.edu/introduction-to-mediation-analysis/

QT:[[”
To analyze mediation:
1. Follow Baron & Kenny’s steps
2. Use either the Sobel test or bootstrapping for significance testing. “]]

WORKS IN PROGRESS – SPRING 2019
Decoding DNA
On the hunt for the genetic roots of mental illnesses

By Marcus Banks | March 4, 2019

QT:[[”
The model, a form of artificial intelligence, aims to use abstract knowledge gained in the research lab to improve clinical treatments for real patients. The ultimate goal, says Gerstein, is to use the model to develop pharmaceutical treatments that reduce the impact of schizophrenia. Part of the challenge in developing drugs to treat the disease is the fact that it is not a one-size-fits-all condition. “]]

https://theamericanscholar.org/decoding-dna/#.XH7RRlNKiqA