linkstream2 microblog

https://www.nature.com/ng/journal/v47/n3/full/ng.3214.html

Big Bang model of…tumor growth, v. slow #evolution under selection https://www.Nature.com/ng/journal/v47/n3/full/ng.3214.html #Cancer is born w/ key mutations all there

Andrea Sottoriva,
Haeyoun Kang,
Zhicheng Ma,
Trevor A Graham,
Matthew P Salomon,
Junsong Zhao,
Paul Marjoram,
Kimberly Siegmund,
Michael F Press,
Darryl Shibata
& Christina Curtis

Nature Genetics 47, 209–216 (2015) doi:10.1038/ng.3214

Seq. variants influencing…TF occupancy
http://www.Nature.com/ng/journal/v47/n12/full/ng.3432.html Uses allelic analysis to develop the CATO score, how variants alter binding

QT:{{”
This approach resulted in a simple scoring scheme, termed contextual analysis of transcription factor occupancy (CATO), that provides a recalibrated probability of affecting the binding of any transcription factor, as well as a quantitatively ranked list of transcription factor families whose binding might be altered.
“}}

#IHECpapers rollout http://www.Cell.com/consortium/ihec Gr8 work! incl. #privacy, normal breast epigenetics, ETG links, deconvolution, #allelic activity

.@RedMonk Programming Language Rankings
http://redmonk.com/sogrady/2016/07/20/language-rankings-6-16/ Now in a period of little change after an initial “Cambrian” diversification

Microphones appear near audio jack on RHS
as described in step 23

https://www.ifixit.com/Teardown/Retina+Macbook+2015+Teardown/39841

Poster of -Seq expts from @Illumina
http://www.illumina.com/content/dam/illumina-marketing/documents/applications/ngs-library-prep/ForAllYouSeqMethods.pdf Nextgen update to @Roche’s famous biochem. #pathway chart
http://biochemical-pathways.com/#/map/1

Originally Boehringer Mannheim chart of pathways

http://web.expasy.org/pathways/

Nice overview of the programs

http://commonfund.nih.gov/initiativeslist

http://www.genomeweb.com/informatics/bina-wins-1m-va-million-veteran-program-contract

Bina Wins $1M VA Million Veteran Program Contract
October 09, 2014

Splicing changes along the blood lineage, good ex. of the
state-of-the-art in human transcriptomics
http://www.sciencemag.org/content/345/6204/1251033.abstract

Science 26 September 2014:
Vol. 345 no. 6204
DOI: 10.1126/science.1251033

Transcriptional diversity during lineage commitment of human blood progenitors

Chen et al.

Protein… #network of alternatively spliced isoforms from brain…: Half of the interactions from #splicing variants
http://www.nature.com/ncomms/2014/140411/ncomms4650/abs/ncomms4650.html