Posts Tagged ‘genetics’

The Height Gap – The New Yorker

Sunday, September 18th, 2016

The #Height Gap – betw. individuals more rel. w. genes but betw. populations w. environment Why Americans are short!

Genetics And That Striped Dress

Saturday, May 2nd, 2015

Genetics & That Striped Dress @23andme on-the-fly SNP associations w/ pop trends. Next: targeting ads w/ alleles

Identification of a large set of rare complete human knockouts : Nature Genetics : Nature Publishing Group

Friday, April 3rd, 2015

A large set [1171] of rare complete human knockouts ~8% Icelanders have one; from a larger set of ~5K genes w/ #LOFs


In Iceland’s DNA, New Clues to Disease-Causing Genes –

by Carl Zimmer
The Decode researchers looked for human knockouts in Iceland — and found a lot of them. Nearly 8 percent of Icelanders lack a working version of a gene. All told, the Decode team identified 1,171 genes shut down in Icelandic knockouts.
In a 2012 study, Dr. MacArthur and his colleagues were able to identify just 253 genes knocked out in humans.

Convergent transcriptional specializations in the brains of humans and song-learning birds

Sunday, March 15th, 2015

Convergent…specializations in brains of humans & songbirds Both have matching expression patterns across regions

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

Saturday, February 21st, 2015

Human & mouse [mRNA] #methylomes revealed by m6A-seq Conservation across species & conditions (for most sites)

Dan Dominissini,
Sharon Moshitch-Moshkovitz,
Schraga Schwartz,

Rotem Sorek
& Gideon Rechavi

Nature 485, 201–206 (10 May 2012) doi:10.1038/nature11112

High-resolution mapping reveals a conserved, widespread, dynamic meiotically regulated mRNA methylation program

Saturday, February 21st, 2015

High-res mapping reveals a conserved…mRNA methylation program Predicting methyl sites w/ seq., structure & position

Cell. 2013 Dec 5; 155(6): 1409–1421.
Published online 2013 Nov 21. doi: 10.1016/j.cell.2013.10.047 PMCID: PMC3956118

High-resolution mapping reveals a conserved, widespread, dynamic meiotically regulated mRNA methylation program

Schraga Schwartz,1,* Sudeep D. Agarwala,2,* Maxwell R. Mumbach,1 Marko Jovanovic,1 Philipp Mertins,1 Alexander Shishkin,1 Yuval Tabach,3,4 Tarjei S Mikkelsen,1 Rahul Satija,1 Gary Ruvkun,3,4 Steven A. Carr,1 Eric S. Lander,1,5,6 Gerald R. Fink,1,2,8 and Aviv Regev 1,7,8

Searching for missing heritability: Designing rare variant association studies

Sunday, October 5th, 2014

Searching for missing heritability… rare variant association studies Pessimistic on #RVAS in #noncoding regions

Nice overview of study design. Good journal-club material.

‘A Troublesome Inheritance’ and ‘Inheritance’

Sunday, August 10th, 2014

‘A Troublesome Inheritance’ and ‘Inheritance’—Lives/dp/1455549444

available via audible

One can find more productive ways to think about genes. As a physician who researches and treats rare genetic disorders, Sharon Moalem, the author of “Inheritance,” sees firsthand how sharply DNA can constrain our lives. Yet “our genes aren’t as fixed and rigid as most of us have been led to believe,” he says, for while genetic defects often create havoc, variable gene expression (our genes’ capacity to respond to the environment with a flexibility only now being fully recognized) can give our bodies and minds surprising resilience. In his new book, Moalem describes riveting dramas emerging from both defective genes and reparative epigenetics.

Neutral genomic regions refine models of recent rapid human population growth

Sunday, January 19th, 2014

Neutral genomic regions refine models of recent rapid human population growth

Elodie Gazave, Li Ma, Diana Chang, Alex Coventry, Feng Gao, Donna Muzny, Eric Boerwinkle, Richard A. Gibbs, Charles F. Sing, Andrew G. Clark, and Alon Keinan

Recent rapid growth of human populations predicts that a large number of genetic variants in populations today are very rare, i.e., appear in a small number of individuals. This effect is similar to that of purifying selection, which drives deleterious alleles to become rarer. “}}

Malcolm Gladwell: Do Genetic Advantages Make Sports Unfair? : The New Yorker

Tuesday, September 3rd, 2013



In athletic competitions, what qualifies as a sporting chance?


Do #Genetic Advantages Make #Sports Unfair? In contrast to doping, corrective operations, &c MT @drbachinsky