linkstream2 microblog

[Population] genetics of Mexico by @cdbustamante lab
http://www.sciencemag.org/content/344/6189/1280.abstract Has groups as divergent from each other as Europeans v Asians

QT:{{”
We found striking genetic stratification among indigenous populations within Mexico at varying degrees of geographic isolation. Some groups were as differentiated as Europeans are from East Asians.
Pre-Columbian genetic substructure is recapitulated in the indigenous ancestry of admixed mestizo individuals across the country.

The genetics of indigenous Mexicans exhibit substantial geographical structure, some as divergent from each other as are existing populations of Europeans and Asians.
“}}

The fine-scale genetic structure of the British population
http://www.nature.com/nature/journal/v519/n7543/full/nature14230.html Correlation w. geography, reflecting Anglo-Saxon migration

http://www.nature.com/nature/journal/v519/n7543/full/nature14230.html

Mtn gorilla genomes reveal…impact of long-term…inbreeding http://www.sciencemag.org/content/348/6231/242 Pop. variation so low that very deleterious SNPs purged

Science 10 April 2015:
Vol. 348 no. 6231 pp. 242-245
DOI: 10.1126/science.aaa3952

Mountain gorilla genomes reveal the impact of long-term population decline and inbreeding

Yali Xue1,*,
Javier Prado-Martinez2,*,
Peter H. Sudmant3,*,
…
Tomas Marques-Bonet2,12,
Chris Tyler-Smith1,†,
Aylwyn Scally13,†

Removing deleterious mutations in Europeans [v] Africans
http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3186.html Comparing nonsynonymous freq. betw. populations HT @obahcall

Neutral genomic regions refine models of recent rapid human population growth

Elodie Gazave, Li Ma, Diana Chang, Alex Coventry, Feng Gao, Donna Muzny, Eric Boerwinkle, Richard A. Gibbs, Charles F. Sing, Andrew G. Clark, and Alon Keinan

QT:{{”
Recent rapid growth of human populations predicts that a large number of genetic variants in populations today are very rare, i.e., appear in a small number of individuals. This effect is similar to that of purifying selection, which drives deleterious alleles to become rarer. “}}

QT:”
We estimate that approximately 73% of all protein-coding SNVs and approximately 86% of SNVs predicted to be deleterious arose in the past 5,000–10,000 years.
”

6,515 #exomes reveals the recent origin of most human protein-coding variants: ~75% #SNVs arose in last ~7.5K yrs
http://www.nature.com/nature/journal/v493/n7431/full/nature11690.html

pos. sel. from 1000G phase 1

http://www.cell.com/retrieve/pii/S0092867413000871
Cell, Volume 152, Issue 4, 703-713, 14 February 2013
Copyright © 2013 Elsevier Inc. All rights reserved.
10.1016/j.cell.2013.01.035
Sharon R. Grossman,Kristian G. Andersen,Ilya Shlyakhter,Shervin Tabrizi,Sarah Winnicki,Angela Yen,Daniel J. Park,Dustin
Griesemer,Elinor K. Karlsson,Sunny H. Wong,Moran Cabili,Richard A. Adegbola,Rameshwar N.K. Bamezai,Adrian V.S. Hill,Fredrik O.
Vannberg,John L. Rinn,1000 Genomes Project,Eric S. Lander,Stephen F. Schaffner,Pardis C. Sabeti

Hum Genet. 2012 Oct 10.
Ostrer H, Skorecki K.
Departments of Pathology and Genetics, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
http://www.ncbi.nlm.nih.gov/pubmed/23052947

Admixture analysis

http://www.sciencemag.org/content/336/6082/740