Posts Tagged ‘1000g’

The Genetic Legacy of the Mongols

Friday, June 29th, 2018

Am J Hum Genet. 2003 Mar; 72(3): 717–721.
Published online 2003 Jan 17. doi: 10.1086/367774
PMCID: PMC1180246
PMID: 12592608

The Genetic Legacy of the Mongols

Tatiana Zerjal,1 Yali Xue,1,2 Giorgio Bertorelle,3 R. Spencer Wells,4 Weidong Bao,1,5 Suling Zhu,1,5 Raheel Qamar,1,6Qasim Ayub,1,6 Aisha Mohyuddin,1,6 Songbin Fu,2 Pu Li,2 Nadira Yuldasheva,4,7 Ruslan Ruzibakiev,7 Jiujin Xu,5Qunfang Shu,5 Ruofu Du,5 Huanming Yang,5 Matthew E. Hurles,8 Elizabeth Robinson,1,* Tudevdagva
Gerelsaikhan,1,†Bumbein Dashnyam,9 S. Qasim Mehdi,5 and Chris Tyler-Smith1

T. Zerjal et al., “The Genetic Legacy of the Mongols,” American Journal of Human Genetics 72 (2003): 717–21.

1000 Genomes Samples sequenced deeply by Illumina, Inc

Saturday, May 12th, 2018

Here is the link to the new 150 deeply Illumina- sequenced 1000 Genomes samples…

There is also a planned trio panel (51 trios) and a repeat expansion project.

search variants in 10000+ genomes

Monday, December 5th, 2016

Hum. Longevity

Human Genome Project: Twenty-five years of big biology

Saturday, October 17th, 2015

HGP: 25yrs of big biology 6 lessons: embrace Partnering, data Sharing & Analytics + Tech & ELSI; be Bold & Flexible

Embrace partnerships. By necessity, the HGP broke the mould of individual researchers toiling away in isolation to answer a small set of scientific questions. It also ran against the grain of
hypothesis-driven research, focusing instead on the discovery of fundamental information that would inform many follow-on


Variety of life : Nature News & Comment

Thursday, October 8th, 2015

The fine-scale genetic structure of the British population : Nature : Nature Publishing Group

Saturday, July 11th, 2015

The fine-scale genetic structure of the British population Correlation w. geography, reflecting Anglo-Saxon migration

No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans : Nature Genetics : Nature Publishing Group

Sunday, January 18th, 2015

Removing deleterious mutations in Europeans [v] Africans Comparing nonsynonymous freq. betw. populations HT @obahcall

The genomic landscape of Neanderthal ancestry in present-day humans : Nature : Nature Publishing Group

Saturday, November 1st, 2014

The genomic landscape of #Neanderthal ancestry in…humans Regions enriched & depleted in ancient alleles, from 1000G

1004 indiv. => 1000G phase 1

Here, we have systematically inferred Neandertal haplotypes in the genomes of 1,004 present-day humans. Regions that harbor a high frequency of Neandertal alleles in modern humans are enriched for genes affecting keratin filaments suggesting that Neandertal alleles may have helped modern humans adapt to non-African environments. Neandertal alleles also continue to shape human biology, as we identify multiple Neandertal-derived alleles that confer risk for disease. We also identify regions of millions of base pairs that are nearly devoid of Neandertal ancestry and enriched in genes, implying selection to remove genetic material derived from Neandertals. “}}

Million Veteran Program (MVP)

Tuesday, June 24th, 2014

Principal Investigators :

John Concato, M.D., M.S., M.P.H.

J. Michael Gaziano, M.D., M.P.H.


It’s Launch Time for the Million Veteran Program…

The VA Office of Research and Development is launching its
unprecedented partnership between VA and Veterans who volunteer to help build one of the largest databases of genetic, military exposure and health information. The Million Veteran Program (MVP) promises to reshape the field of genomics—a sophisticated science poised to revolutionize health care for Veterans and others throughout the U.S. and around the world.


From Schmidt’s talk: The Million Veteran Program is building a DB of genetic, military exposure & health info #1000gb

amino acid changes in 1000 Genomes Project Thornton Lab

Monday, June 23rd, 2014

1000G v disease variants