linkstream2 microblog

HGP: 25yrs of big biology
http://www.nature.com/news/human-genome-project-twenty-five-years-of-big-biology-1.18436 6 lessons: embrace Partnering, data Sharing & Analytics + Tech & ELSI; be Bold & Flexible

QT:{{”
Embrace partnerships. By necessity, the HGP broke the mould of individual researchers toiling away in isolation to answer a small set of scientific questions. It also ran against the grain of
hypothesis-driven research, focusing instead on the discovery of fundamental information that would inform many follow-on
investigations.
…
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QT:{{”
“We have around 24,000 genes that make us uniquely human and, until now, it was thought that if any were missing it could cause serious problems.

But new research has found that around 200 of these genes may in fact be completely redundant, without posing any such risk.

By studying the genomes of 2,500 people, researchers have said they were surprised to see around one per cent of these genes were missing entirely in some participants.

More importantly, these particular people had no significant health defects that would be explained by the missing genes.
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http://www.dailymail.co.uk/sciencetech/article-3256030/More-200-genes-USELESS-Genome-project-finds-not-need-DNA-survive.html

http://www.nih.gov/news/health/sep2015/nhgri-30.htm

http://www.independent.co.uk/news/science/human-genome-study-reveals-certain-genes-are-less-essential-than-previously-thought-a6674001.html

https://www.genomeweb.com/clinical-sequencing/scientists-1000-genomes-consortium-create-largest-catalog-human-genomic

http://www.nature.com/news/human-genome-project-twenty-five-years-of-big-biology-1.18436

http://www.nature.com/nature/journal/v526/n7571/full/526052a.html

http://www.nature.com/news/variety-of-life-1.18454

http://www.dailymail.co.uk/sciencetech/article-3256030/More-200-genes-USELESS-Genome-project-finds-not-need-DNA-survive.html

http://news.yale.edu/2015/09/30/research-news-catalogue-human-genetic-variation-revealed