linkstream2 microblog

two papers for journal club:

1. What are super-enhancers? Pott et al., Nature Genetics (2015) http://www.nature.com/ng/journal/v47/n1/full/ng.3167.html

2. Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer, Heyn et al., Genome Biology (2016)
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-0879-2

#Epigenomic analysis detects aberrant super-enhancer DNA methylation in human #cancer
https://GenomeBiology.biomedcentral.com/articles/10.1186/s13059-016-0879-2 hypo-Me of many large blocks

Celltype & region–resolved mouse brain proteome
http://www.nature.com/neuro/journal/v18/n12/full/nn.4160.html proteins enriched there v liver & in specific regions (eg NCX v STR)

http://www.nature.com/neuro/journal/v18/n12/full/nn.4160.html

Panorama of ancient metazoan #macromolecular complexes
http://www.nature.com/nature/journal/v525/n7569/abs/nature14877.html Finding many more #complexes from integrating many co-elutions

http://www.nature.com/nature/journal/v525/n7569/full/nature14877.html#affil-auth

Punctuated equilibrium in the large-scale #evolution of #programming languages http://rsif.royalsocietypublishing.org/content/12/107/20150249 Clustering groups these into trees

Punctuated equilibrium in the large-scale evolution of programming languages
Sergi Valverde, Ricard V. Solé

#Chromatin…shapes the mutational landscape of cancer
http://www.nature.com/nature/journal/v518/n7539/full/nature14221.html Low DNase correlates w/ high SNVs in melanoma. True generally?

Multiple hypothesis testing in genomics
http://onlinelibrary.wiley.com/doi/10.1002/sim.6082/full Nice overview, comparing familywise error & FDR control + FDP estimation

http://www.few.vu.nl/~mavdwiel/HDDA/tutorial_multtest.pdf

QT:{{”
This paper presents an overview of the current state-of-the-art in multiple testing in genomics data from a user’s perspective. We describe methods for familywise error control, false discovery rate control and false discovery proportion estimation and confidence, both conceptually and practically, and explain when to use which type of error rate. We elaborate the assumptions underlying the methods, and discuss pitfalls in the interpretation of results. In our discussion we take into account the exploratory nature of genomics experiments, looking at selection of genes before or after testing, and at the role of validation experiments.
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DNA sequence…#compression
http://bib.oxfordjournals.org/content/16/1/1.full Nice review comparing approaches on 2 axes: classic v Nextgen & reference-based v -free

Not much on LD-based approaches

Zexuan Zhu
Yongpeng Zhang
Zhen Ji
Shan He
Xiao Yang

Brief Bioinform (2015) 16 (1): 1-15.doi: 10.1093/bib/bbt087
First published online: December 3, 2013

Massive Genomic Decay in… a Recently Evolved #Symbiont of Aphids. Creation of #pseudogenes in many COG categories
http://gbe.oxfordjournals.org/content/3/195.long

Gaelen R. Burke & Nancy A. Moran