CTCF-Mediated…3D Genome Architecture
http://www.cell.com/cell/abstract/S0092-8674(15)01504-4 SNPs give different #chromatin topologies, including strong #allelic effects
New grant format w/ prelim. results under significance v. approach as nowhttp://grants.nih.gov/grants/guide/notice-files/NOT-OD-16-011.html @NIH notice is cryptic. People’s thoughts?
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need to use strength & weakness for each citation.
see also:
http://www.grantcentral.com/wp-content/uploads/2015/12/Supplement-Changes-in-Approach-Subsection.pdf http://grants.nih.gov/grants/forms_updates_faq.htm#2426
http://grants.nih.gov/grants/funding/424/index.htm
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One of the changes to this Chapter pertains to the format for the Approach subsection, which is reproduced, above. “Justification and Feasibility” and its two subdivisions have been lined out because, with the new approach that we recommend, they are no longer part of the Approach subsection. (We have moved them to the Significance subsection, Chapter 9). Without those components, the formatting for each aim “collapses” to include the Introductory Paragraph, Research Design, Expected Outcomes and Potential Problems & Alternative Strategies.
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Updates to Research Strategy Guidance
By November 25, 2015 application guide instructions will be updated to include the following additional guidance for the Significance and Approach sections of the Research Strategy, in addition to the existing instructions.
Significance
Describe the scientific premise for the proposed project, including consideration of the strengths and weaknesses of published research or preliminary data crucial to the support of your application. Approach
Describe the experimental design and methods proposed and how they will achieve robust and unbiased results.
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http://www.cell.com/cell/pdf/S0092-8674(15)01504-4.pdf