http://science.sciencemag.org/content/359/6376/693.full
+
perspective
http://science.sciencemag.org/content/359/6376/619.full
Gene Expression Overlaps Among Psychiatric Disorders
Transcriptional profiling of post-mortem human brains reveals commonalities in the genes over- and under-expressed in schizophrenia, bipolar disorder, autism, and major depression.
Understanding the Brain: The Neurobiology of Everyday Life
https://www.coursera.org/learn/neurobiology
Paper about what will be on eGTEx project:
https://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3969.html
Gtex Nature
https://www.nature.com/nature/journal/v550/n7675/full/nature24267.html https://www.nature.com/nature/journal/v550/n7675/full/nature24265.html https://www.nature.com/nature/journal/v550/n7675/full/nature24041.html http://www.nature.com/nature/journal/v550/n7675/full/nature24277.html
Eval of Chromatin Accessibility [via #ATACSeq] in DLPFC of SCZ Cases/Ctrls, by @JulienBryois et al.
http://www.BiorXiv.org/content/early/2017/05/25/141986 List of cQTLs
.@GeoChurch ascribes his…ideas to narcolepsy
https://www.StatNews.com/2017/06/08/george-church-narcolepsy Advocates more neurodiversity, ie those w. ASD, OCD, ADD + narcolepsy
QT:{{”
“His condition has persuaded Church of the benefits of, even the need for, neurodiversity, meaning brains that work differently from most others. The world needs people with high-functioning autism and obsessive-compulsive disorder and attention deficit disorder and, yes, narcolepsy, he has come to believe.”
“}}
http://genome-tech.ucsd.edu/public/Lake_Science_2016/
https://twitter.com/mikejg84/status/880240608144531456
16 Neuronal subtypes & [inter-regional] diversity revealed by [#singlecell]-nucleus RNAseq of…the brain
http://science.sciencemag.org/content/352/6293/1586.long
Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain.
Lake BB, Ai R, Kaeser GE, Salathia NS, Yung YC, Liu R, Wildberg A, Gao D, Fung HL, Chen S, Vijayaraghavan R, Wong J, Chen A, Sheng X, Kaper F, Shen R, Ronaghi M, Fan JB, Wang W, Chun J, Zhang K.
Science. 2016 Jun 24;352(6293):1586-90. doi: 10.1126/science.aaf1204.
Brain #transcriptome diversity at the single cell level
http://www.PNAS.org/content/112/23/7285 Has useful gene-exp. profiles of specific neural cell types
has profiles for 185 biomarker genes for 6 cell types
QT:{{”
“This shift has been having profound impacts on mental-health research in the United States, but the magnitude of the transformation is only now coming to light. An analysis by Nature suggests that the number of clinical trials funded by the NIMH dropped by 45% between 2009 and 2015 (see ‘’). This coincides with the agency’s launch, in 2011, of the Research Domain Criteria (RDoC) — a framework for research on the mechanisms of mental illness. The NIMH’s roll-out of RDoC included asking researchers to focus more on the biological bases of behaviour — such as brain circuitry and genetics — than on the broader symptoms that clinicians typically use to define and classify mental illness.
The NIMH’s embrace of fundamental research has infuriated many clinical researchers, who see it as an attempt to invalidate their methods — and say that there is scant evidence to support the idea that using RDoC will lead to greater insight or better treatments for mental illness.”
“}}
US mental-health agency’s push for basic research has slashed support for clinical trials
http://www.nature.com/news/us-mental-health-agency-s-push-for-basic-research-has-slashed-support-for-clinical-trials-1.22145