linkstream2 microblog

https://www.biorxiv.org/content/10.1101/762773v1

https://www.sciencedirect.com/science/article/pii/S0092867419310724?dgcid=author

Rebecca L. Walker, Gokul Ramaswami, Christopher Hartl, Nicholas Mancuso, Michael J. Gandal, Luis de la Torre-Ubieta, Bogdan Pasaniuc, Jason L. Stein, Daniel H. Geschwind,

Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms,

Cell,

Volume 179, Issue 3,
2019,
Pages 750-771.e22,
ISSN 0092-8674,
https://doi.org/10.1016/j.cell.2019.09.021

A global overview of pleiotropy and genetic architecture in complex traits

Kyoko Watanabe, Sven Stringer, Oleksandr Frei, Maša Umićević Mirkov, Christiaan de Leeuw, Tinca J. C. Polderman, Sophie van der Sluis, Ole A. Andreassen, Benjamin M. Neale & Danielle Posthuma

https://www.nature.com/articles/s41588-019-0481-0

QT:{{”

Tabula Muris is a compendium of single cell transcriptome data from the model organism Mus musculus, containing nearly 100,000 cells from 20 organs and tissues. The data allow for direct and controlled comparison of gene expression in cell types shared between tissues, such as immune cells from distinct anatomical locations. They also allow for a comparison of two distinct technical approaches: “}}

https://tabula-muris.ds.czbiohub.org/

https://www.spectrumnews.org/wiki/shank3/

From Zhu et al. Science (’18)
QT:{{”
Further analysis revealed that the ASD-associated genes SHANK2 and SHANK3, which encode synaptic scaffolding proteins at the postsynaptic density of excitatory glutamatergic synapses, exhibited earlier expression in the macaque NCX and other brain regions relative to humans (Fig. 7B).
“}}

https://www.nature.com/articles/s41467-018-05379-y

https://onlinelibrary.wiley.com/doi/full/10.1002/ajmg.b.32545

assoc w. SCZ+Chron’s
protective to Parkinson’s

https://www.ncbi.nlm.nih.gov/pubmed/30545852
gsp

https://onlinelibrary.wiley.com/doi/full/10.1002/ajmg.b.32545

assoc w. SCZ+Chron’s
protective to Parkinson’s

https://www.protocols.io/groups/hca