linkstream2 microblog

Looks useful!

http://nar.oxfordjournals.org/content/early/2013/11/24/nar.gkt1188

It look as though the data are now ready for download
http://datasets.pacb.com/2013/Human10x/READS/index.html along with a brief description of the data
http://blog.pacificbiosciences.com/2013/10/data-release-long-read-shotgun.html

http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1003709#pgen-1003709-g006
This paper discusses gene intolerance score — very similar to depletion of common polymorphisms. They don’t analyze non-coding regions — this is using exome data only. Blue for tolerant and red for intolerant (see Figure 1) .

http://news.sciencemag.org/scienceinsider/2013/06/-qa-david-altshuler-on-how-to-sh.html
But how will a little player participate in this? MT @gtyrelle: Q&A: on How to Share Millions of Human Genomes http://bit.ly/19jlKNs

http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.2658.html Uses only CG data for variation, only TFBS data form ENCODE. QT:”the binding sites of several transcription factors show clear evidence of adaptation.”

http://www.sciencemag.org/content/340/6133/682.1.full

http://www.nature.com/nbt/journal/v30/n11/full/nbt.2422.html

Hum Genet. 2012 Oct 10.
Ostrer H, Skorecki K.
Departments of Pathology and Genetics, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
http://www.ncbi.nlm.nih.gov/pubmed/23052947

Admixture analysis

http://www.foxnews.com/health/2012/11/01/1000-genomes-project-moves-researchers-closer-to-personalized-medicine/

http://www.nih.gov/news/health/oct2012/nhgri-31.htm