Posts Tagged ‘possel’

A naturally occurring variant of the human prion protein completely prevents prion disease : Nature : Nature Publishing Group

Friday, August 14th, 2015

Natural variant of the…#prion protein [G127V] completely
prevents…disease Under pos. selection for kuru afflicted

A novel PrP variant, G127V, was under positive evolutionary selection during the epidemic of kuru—an acquired prion disease epidemic of the Fore population in Papua New Guinea—and appeared to provide strong protection against disease in the heterozygous state2. Here we have investigated the protective role of this variant and its interaction with the common, worldwide M129V PrP polymorphism. V127 was seen exclusively on a M129 PRNP allele. We demonstrate that transgenic mice expressing both variant and wild-type human PrP are completely resistant to both kuru…”

Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude

Thursday, May 8th, 2014

Contains a tree-based way of determining positive selection

1000 Genomes Selection Browser 1.0: a genome browser dedicated to signatures of natural selection in modern humans

Sunday, December 1st, 2013

Looks useful!