linkstream2 microblog

Am J Hum Genet. 2003 Mar; 72(3): 717–721.
Published online 2003 Jan 17. doi: 10.1086/367774
PMCID: PMC1180246
PMID: 12592608

The Genetic Legacy of the Mongols

Tatiana Zerjal,1 Yali Xue,1,2 Giorgio Bertorelle,3 R. Spencer Wells,4 Weidong Bao,1,5 Suling Zhu,1,5 Raheel Qamar,1,6Qasim Ayub,1,6 Aisha Mohyuddin,1,6 Songbin Fu,2 Pu Li,2 Nadira Yuldasheva,4,7 Ruslan Ruzibakiev,7 Jiujin Xu,5Qunfang Shu,5 Ruofu Du,5 Huanming Yang,5 Matthew E. Hurles,8 Elizabeth Robinson,1,* Tudevdagva
Gerelsaikhan,1,†Bumbein Dashnyam,9 S. Qasim Mehdi,5 and Chris Tyler-Smith1

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180246/

T. Zerjal et al., “The Genetic Legacy of the Mongols,” American Journal of Human Genetics 72 (2003): 717–21.

Here is the link to the new 150 deeply Illumina- sequenced 1000 Genomes samples…

https://www.ebi.ac.uk/ena/data/view/PRJEB20654
https://github.com/Illumina/Polaris/wiki/HiSeqX-Diversity-Panel

There is also a planned trio panel (51 trios) and a repeat expansion project.

https://github.com/Illumina/Polaris/

Hum. Longevity

https://search.hli.io/

HGP: 25yrs of big biology
http://www.nature.com/news/human-genome-project-twenty-five-years-of-big-biology-1.18436 6 lessons: embrace Partnering, data Sharing & Analytics + Tech & ELSI; be Bold & Flexible

QT:{{”
Embrace partnerships. By necessity, the HGP broke the mould of individual researchers toiling away in isolation to answer a small set of scientific questions. It also ran against the grain of
hypothesis-driven research, focusing instead on the discovery of fundamental information that would inform many follow-on
investigations.
…
“}}

http://www.nature.com/news/variety-of-life-1.18454

The fine-scale genetic structure of the British population
http://www.nature.com/nature/journal/v519/n7543/full/nature14230.html Correlation w. geography, reflecting Anglo-Saxon migration

http://www.nature.com/nature/journal/v519/n7543/full/nature14230.html

Removing deleterious mutations in Europeans [v] Africans
http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3186.html Comparing nonsynonymous freq. betw. populations HT @obahcall

The genomic landscape of #Neanderthal ancestry in…humans
http://www.nature.com/nature/journal/v507/n7492/full/nature12961.html Regions enriched & depleted in ancient alleles, from 1000G

1004 indiv. => 1000G phase 1

QT:{{”
Here, we have systematically inferred Neandertal haplotypes in the genomes of 1,004 present-day humans. Regions that harbor a high frequency of Neandertal alleles in modern humans are enriched for genes affecting keratin filaments suggesting that Neandertal alleles may have helped modern humans adapt to non-African environments. Neandertal alleles also continue to shape human biology, as we identify multiple Neandertal-derived alleles that confer risk for disease. We also identify regions of millions of base pairs that are nearly devoid of Neandertal ancestry and enriched in genes, implying selection to remove genetic material derived from Neandertals. “}}

http://www.research.va.gov/MVP/

Principal Investigators :

John Concato, M.D., M.S., M.P.H.
Yale

J. Michael Gaziano, M.D., M.P.H.
Harvard

QT:{{”

It’s Launch Time for the Million Veteran Program…

The VA Office of Research and Development is launching its
unprecedented partnership between VA and Veterans who volunteer to help build one of the largest databases of genetic, military exposure and health information. The Million Veteran Program (MVP) promises to reshape the field of genomics—a sophisticated science poised to revolutionize health care for Veterans and others throughout the U.S. and around the world.

“}}

From Schmidt’s talk: The Million Veteran Program is building a DB of genetic, military exposure & health info
http://www.research.va.gov/MVP #1000gb

1000G v disease variants
http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1003382