Primate Transcript and Protein #Expression Levels Evolve Under Compensatory #Selection Pressures: [Protein]<[mRNA]
https://www.sciencemag.org/content/342/6162/1100
Are Isle Royale’s Wolves Chasing Extinction? Maybe from
#globalwarming; now population of ~10 wolves & ~1000 moose
http://www.sciencemag.org/content/340/6135/919.summary
Evidence of Abundant Purifying Selection in Humans for Recently Acquired Regulatory Functions
L Ward & M Kellis
http://www.sciencemag.org/content/337/6102/1675.abs
In general we know that conservation across species and within humans are correlated. In this paper the authors focus on emphasize the exceptions to this trend. They show that although only ~5% of the human genome is conserved across mammals, regulatory regions in an additional 4% of the genomes are conserved amongst humans. They also show that some elements are conserved across mammals but lack functional activity from ENCODE data and also do not show purifying selection amongst humans. The authors pinpoint regulatory regions near color vision and nerve-growth genes for that show human-specific constraint. This has been criticized in various publications since there are other genes that are higher up in the authors’ list but harder to explain for lineage-specific constraint.
http://www.ncbi.nlm.nih.gov/pubmed/23176822
Am J Hum Genet. 2012 Dec 7;91(6):1033-40. doi:
10.1016/j.ajhg.2012.10.018. Epub 2012 Nov 21.
Differential relationship of DNA replication timing to different forms of human mutation and variation.
Koren A, Polak P, Nemesh J, Michaelson JJ, Sebat J, Sunyaev SR, McCarroll SA.
Great tidbits on how olives & wine seem less sour together than individually
Following the Flavor. Great tidbits on retronasal olfaction & how combos #taste different together than individually
http://www.sciencemag.org/content/340/6134/808.summary
http://www.sciencemag.org/content/340/6134/1235009.abstract
Impact of Shale #Gas Development on Regional Water Quality: Disposal of #fracking wastewater will be a future issue
http://www.sciencemag.org/content/340/6134/1235009.abstract
Trnp1 Regulates Expansion and Folding of the Mammalian Cerebral #Cortex: less in mice gives more human-like folds
http://www.cell.com/retrieve/pii/S0092867413003498
Glossary of Their Quarry. #exoplanet types: circumbinary, pulsar, core & rogue. Hot Jupiters, waterworlds, #exomoons
http://www.sciencemag.org/content/340/6132/570.summary
And a Glossary of Their Quarry.
Quoting from the podcast summary…
QT:{{”
So far, scientists have uncovered over 800 exoplanets roaming the cosmos—but as Sara Seager said earlier, we’re still searching for that Earth-like, Goldilocks planet.
…
Most of the planets we’ve discovered up until this point are what’s called Hot
Jupiters, which are gas giants about the size of Jupiter in our solar system with a pretty
big range on either side, so the smallest Hot Jupiters would be about 50 Earth masses.
…
The nastiest place to live would probably be pulsar planets.
…
And I
think another really unpleasant place to be would be a core planet. So core planets, they
sort of resemble something like Mercury, the size of Mercury, maybe even smaller.
…
I think just like in the solar system, actually, some of the best places for potentially
finding life outside of our solar system might be moons. So we call them exomoons or
moons orbiting exoplanets.
…
But we have seen and are seeing more and more of are theses
circumbinary planets,
which means a planet with two suns. So, Tatooine is sort of the iconic example.
…
Yes, waterworlds. So those are pretty diverse, and they are usually super-Earth-size so
they’ll be like 10 times the mass of Earth.
…
And then there are some planets that just go rogue.
“}}
http://onlinelibrary.wiley.com/doi/10.1111/eci.12171/full
~15M authors => ~150K w/ H>=20 => ~500 w/ highest citations &/or H >75 => 407 w/ further filters => 13 in Genomics & 4 from Yale