linkstream2 microblog

Analysis of the Sputum Transcriptome Discriminates Clinical Phenotypes of Asthma http://www.atsjournals.org/doi/abs/10.1164/rccm.201408-1440OC Consistent blood expression patterns

Noninvasive Analysis of the Sputum Transcriptome Discriminates
Clinical Phenotypes of Asthma (ATS Journals)

Yan, X., Chu, J.-H., Gomez, J., Koenigs, M., Holm, C., He, X., Perez,
M. F., Zhao, H., Mane, S., Martinez, F. D., Ober, C., Nicolae, D. L.,
Barnes, K. C., London, S. J., Gilliland, F., Weiss, S. T., Raby, B.
A., Cohn, L., and Chupp, G. L. “Non-Invasive Analysis of the Sputum
Transcriptome Discriminates Clinical Phenotypes of Asthma” American
Journal of Respiratory and Critical Care Medicine (2015):
doi:10.1164/rccm.201408-1440OC,

QT:{{"
Conclusions: There are common patterns of gene expression in the
sputum and blood of children and adults that are associated with near
fatal, severe and milder asthma.
"}}

Mtn gorilla genomes reveal…impact of long-term…inbreeding http://www.sciencemag.org/content/348/6231/242 Pop. variation so low that very deleterious SNPs purged

Science 10 April 2015:
Vol. 348 no. 6231 pp. 242-245
DOI: 10.1126/science.aaa3952

Mountain gorilla genomes reveal the impact of long-term population decline and inbreeding

Yali Xue1,*,
Javier Prado-Martinez2,*,
Peter H. Sudmant3,*,
…
Tomas Marques-Bonet2,12,
Chris Tyler-Smith1,†,
Aylwyn Scally13,†

ALK Mutations Confer Differential Oncogenic Activation
http://www.cell.com/cancer-cell/abstract/S1535-6108%2814%2900393-6 MD modeling better assessing #SNV impact than stats, ie sift

ALK Mutations Confer Differential Oncogenic Activation and Sensitivity to ALK Inhibition Therapy in Neuroblastoma

Scott C. Bresler
Daniel A. Weiser
Peter J. Huwe
…
Ravi Radhakrishnan
Mark A. Lemmon
Yaël P. Mossé

DOI: http://dx.doi.org/10.1016/j.ccell.2014.09.019

Identifying personal microbiomes using metagenomic codes
http://www.pnas.org/content/early/2015/05/08/1423854112.abstract Pot. tracking & #privacy implications
http://www.the-scientist.com/?articles.view/articleNo/42950/title/Microbiome-Fingerprints

http://www.pnas.org/content/early/2015/05/08/1423854112.abstract

doi: 10.1073/pnas.1423854112

Identifying personal microbiomes using metagenomic codes

Eric A. Franzosa
Katherine Huang
James F. Meadow
Dirk Gevers
Katherine P. Lemond
Brendan J. M. Bohannanc
Curtis Huttenhower

Comparative #genomics reveals insights into avian…#evolution http://www.sciencemag.org/content/346/6215/1311 Less repeats & dups in birds; woodpecker, an exception

Science 12 December 2014:
Vol. 346 no. 6215 pp. 1311-1320
DOI: 10.1126/science.1251385

Comparative genomics reveals insights into avian genome evolution and adaptation

Guojie Zhang1,2,*,†,
Cai Li1,3,*,
….
Avian Genome Consortium§,
Erich D. Jarvis20,†,
M. Thomas P. Gilbert3,56,†,
Jun Wang1,55,57,58,59,†

Characterization of #SVs w. single molecule & hybrid sequencing http://bioinformatics.oxfordjournals.org/content/30/24/3458.abstract Probabilistic read mapping, re-evaluating adjacencies

QT:{{"
We present MultiBreak-SV, an algorithm to detect structural variants
(SVs) from single molecule sequencing data, paired read sequencing
data, or a combination of sequencing data from different platforms.
"}}

Rebooting #MOOC Research https://www.sciencemag.org/content/347/6217/34.summary
Perspective from an #education institution: How to measure engagement of the student?

“this has got to be a record… imported this into Zotero to find the total author count. It’s 1,014”
http://www.g3journal.org/content/5/5/719.abstract

The brain chip http://www.sciencemag.org/content/345/6197/614.summary #Neuromorphic #computers overcome bottlenecks in classic von Neumann architecture

QT:{{"…consists of 20,000 chips, each of which represents 1000 neurons. This fall, Furber says, he expects that number will rise to 100,000 chips representing 100 million neu-rons, and eventually a 1-million-chip system representing 1 billion neurons—about 1% of the neurons in the human brain

All computer chips made today rely on the same general architecture that was outlined nearly 70 years ago. This architecture separates the two primary tasks a chip needs to carry out—processing and memory—into different regions and continuously communicates data back and forth. Though this strategy works well for crunching numbers and running spreadsheets, it’s much less efficient for handling tasks that manage vast amounts of data, such as vision and language processing. But in recent years, researchers around the globe have been pursuing a new approach called neuromorphic computing. On page 668 of this issue, researchers at IBM and Cornell University report creating the world’s first production-scale neuromorphic computing chip. The novel approach to hardware is made up of 5.4 billion transistors that are wired to emulate a brain with 1 million "neurons" that talk to one another via 256 million "synapses."

"}}

His brain, her brain? http://www.sciencemag.org/content/346/6212/915.summary Neurosexism potentially results from multiple testing & only publishing positives