linkstream2 microblog

http://www.americanscientist.org/issues/pub/huygenss-clocks-revisited

#Singlecell ChIPseq reveals…subpopulations defined by chromatin statehttp://www.nature.com/nbt/journal/vaop/ncurrent/full/nbt.3383.html Sparse data: on order of 1K uniq. reads/cell

http://www.nature.com/nbt/journal/vaop/ncurrent/full/nbt.3383.html

HGP: 25yrs of big biology
http://www.nature.com/news/human-genome-project-twenty-five-years-of-big-biology-1.18436 6 lessons: embrace Partnering, data Sharing & Analytics + Tech & ELSI; be Bold & Flexible

QT:{{”
Embrace partnerships. By necessity, the HGP broke the mould of individual researchers toiling away in isolation to answer a small set of scientific questions. It also ran against the grain of
hypothesis-driven research, focusing instead on the discovery of fundamental information that would inform many follow-on
investigations.
…
“}}

A tag of one’s own
http://www.nature.com/naturejobs/science/articles/10.1038/nj7572-281aMakes a convincing case for signing up for an ORCHID identifier & linking it to your papers

http://www.nature.com/nbt/journal/v33/n5/full/nbt.3223.html

Panorama of ancient metazoan #macromolecular complexes
http://www.nature.com/nature/journal/v525/n7569/abs/nature14877.html Finding many more #complexes from integrating many co-elutions

http://www.nature.com/nature/journal/v525/n7569/full/nature14877.html#affil-auth

Systematic humanization of yeast genes reveals conserved functions &…modularity http://www.sciencemag.org/content/348/6237/921.abstract #yeast survive in half of 400 swaps

http://lichtmanlab.fas.harvard.edu/cell-july-2015

Punctuated equilibrium in the large-scale #evolution of #programming languages http://rsif.royalsocietypublishing.org/content/12/107/20150249 Clustering groups these into trees

Punctuated equilibrium in the large-scale evolution of programming languages
Sergi Valverde, Ricard V. Solé

Why human disease-associated residues appear as WT in other species http://mbe.oxfordjournals.org/content/31/7/1787.abstract Compensation by their 3D structural neighbors