linkstream2 microblog

Gene expr. elucidates functional impact of…risk for SCZ
http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.4399.html CMC resource contains >2.1M #eQTLs involving ~1.6M SNPs

NATURE NEUROSCIENCE | ARTICLE

Gene expression elucidates functional impact of polygenic risk for schizophrenia

Menachem Fromer,
Panos Roussos,
Solveig K Sieberts,
Jessica S Johnson,
David H Kavanagh,
Thanneer M Perumal,
Douglas M Ruderfer,
….
Eric E Schadt,
Keisuke Hirai,
Kathryn Roeder,
Kristen J Brennand,
Nicholas Katsanis,
Enrico Domenici,
Bernie Devlin
& Pamela Sklar

Gamma frequency entrainment attenuates amyloid load & modifies microglia http://www.nature.com/nature/journal/v540/n7632/full/nature20587.html Buying a 40 Hz light to fight Alzheimer’s!

Discovering TFBSs in…Repetitive Regions of #Genomes with Multi-Read
Analysis http://journals.PLOS.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002111 CSEM uses EM to refine site occupancy

Chung D, Kuan PF, Li B, SanalKumar R, Liang K, Bresnick E, Dewey C, and Keles S (2011), “Discovering transcription factor binding sites in highly repetitive regions of genomes with multi-read analysis of ChIP-Seq data,” PLoS Computational Biology, 7(7): e1002111

http://www.stat.wisc.edu/~keles/Software/multi-reads/

CSEM

https://toolshed.g2.bx.psu.edu/repository/display_tool?repository_id=e18c78b20646a2aa&tool_config=database%2Fcommunity_files%2F000%2Frepo_83%2Fcsem.xml&changeset_revision=1438767ad92f

DNA sequence…#compression
http://bib.oxfordjournals.org/content/16/1/1.full Nice review comparing approaches on 2 axes: classic v Nextgen & reference-based v -free

Not much on LD-based approaches

Zexuan Zhu
Yongpeng Zhang
Zhen Ji
Shan He
Xiao Yang

Brief Bioinform (2015) 16 (1): 1-15.doi: 10.1093/bib/bbt087
First published online: December 3, 2013