linkstream2 microblog

NYT recently ran an article as well:
http://www.nytimes.com/2014/04/08/business/cancer-analysis-tools-circumvent-biopsies.html

http://www.nature.com/nm/journal/v20/n4/abs/nm.3511.html

An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage
http://www.nature.com/nm/journal/vaop/ncurrent/abs/nm.3519.html

http://stm.sciencemag.org/content/6/224/224ra24
http://www.nejm.org/doi/full/10.1056/NEJMoa1213261

http://stm.sciencemag.org/content/4/162/162ra154.full
DIAGNOSTICS: Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome Sequencing

Developmental dynamics… of random monoallelic gene expression. #RNAseq on 100s of instances without causative SNPs

An analysis of differentiated cell lines.

http://www.cell.com/developmental-cell/abstract/S1534-5807(14)00057-4

Neutral genomic regions refine models of recent rapid human population growth

Elodie Gazave, Li Ma, Diana Chang, Alex Coventry, Feng Gao, Donna Muzny, Eric Boerwinkle, Richard A. Gibbs, Charles F. Sing, Andrew G. Clark, and Alon Keinan

QT:{{”
Recent rapid growth of human populations predicts that a large number of genetic variants in populations today are very rare, i.e., appear in a small number of individuals. This effect is similar to that of purifying selection, which drives deleterious alleles to become rarer. “}}

QT:{{”
To demonstrate the promise of personalized genome analysis, the genome of HuRef was sequenced using the Life SOLiD™ platform. Nimbus Informatics performed the analytical work for this project and has made the resulting data available here, running entirely on the Amazon Cloud.
“}}
http://huref.nimbusinformatics.com

http://database.oxfordjournals.org/content/2013/bat069.abstract.html