Posts Tagged ‘fn’

Microsoft has reportedly acquired GitHub

Monday, June 4th, 2018

Oh no…

miRNA atlas

Tuesday, November 1st, 2016

Distribution of #miRNA expression across human tissues Atlas of ~1400 RNAs in at least 1 of 61 tissues; 143 in all

Slow motion video – 350,000 frames per second!

Saturday, July 23rd, 2016

5 second of footage turns into 19 hours!

Cell lineage analysis in human brain using endogenous retroelements. – PubMed – NCBI

Saturday, May 7th, 2016

Cell-lineage analysis in human #brain using endogenous retroelements Tracing L1 insertions w/ #singlecell sequencing

Using single cell WGS of 16 neuronal cells the authors investigated two somatic insertions of L1Hs elements in an adult human brain. Using these results the authors infer that L1 somatic insertions are infrequent and ALUs and SVAs somatic retrotransposition are extremely rare. Assessing two L1Hs insertions in 32 samples across different regions of this same adult brain, they found that while one insertion was spatially restricted (2x1cm region), the other was found across all samples of the adult brain (but not found in other tissues such as Heart, Lung, etc.). The more restricted one (L1Hs#1) is inferred to have happened during the Fetal stage (first trimester) while the broader one happened earlier, approximately 2 weeks
post-fertilization. Overall the paper is clear, concise, and simple. It answers an interesting biological question: Can retrotransposition be used as a marker of cell clonal expansion? It does, although the retrotransposition frequency is very small and SNVs might support better results for the same analysis due to their higher frequency..

L1 – Somatic – Brain – Single cell DNA

Friday, August 7th, 2015

Cell Lineage Analysis in Human Brain Using Endogenous Retroelements Somatic events from #neuron #singlecell WGS