Posts Tagged ‘encodenets’

The Transcription Factor Titration Effect Dictates Level of Gene Expression

Sunday, April 6th, 2014

Interesting study looking at the effect of gene duplication on TF binding
"…when a TF is shared among many binding sites, either due to multiple identical copies of a gene regulated by that TF or due to unrelated genes that also independently bind the TF, the correlation in occupancy between the binding sites will lead to a complex dosage response to that TF."

correlated noise in TF co-association / FFLs

Saturday, March 9th, 2013

Cross Talk and Interference Enhance Information Capacity of a Signaling Pathway Sahand Hormoz
A recurring motif in gene regulatory networks is transcription factors (TFs) that regulate each other and then bind to overlapping sites on DNA, where they interact and synergistically control transcription of a target gene. Here, we suggest that this motif maximizes information flow in a noisy network. Gene expression is an inherently noisy process due to thermal fluctuations and the small number of molecules involved. A consequence of multiple TFs interacting at overlapping binding sites is that their binding noise becomes correlated. Using concepts from information theory, we show that in general a signaling pathway transmits more information if 1), noise of one input is correlated with that of the other; and 2), input signals are not chosen independently.

What were the top papers of 2012 on social media? : Nature News Blog

Friday, March 8th, 2013 encodenets within one of the top-10 lists