Policy-relevant proportions for direct effects
April 1st, 2019https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523303/
discusses NDE & NIE
neuroDEVELOPMENTS: Neuroscience Research to Clinical Relevance
April 1st, 2019https://mailchi.mp/add7f814b67d/neurodevelopments-720229
https://www.libd.org/neurodevelopments/
the Lieber’s neuroDEVELOPMENTS newsletter, which features the PsychENCODE paper
politics questions galore
April 1st, 2019prediction markets
https://www.predictit.org/
A Decade of GWAS Results in Lung Cancer | Cancer Epidemiology, Biomarkers & Prevention
April 1st, 2019http://cebp.aacrjournals.org/content/27/4/363.long
QT:[[”
The first GWAS on lung cancer were reported in 2008. Three independent studies identified a susceptibility locus on chromosome 15q. Hung and colleagues (14) found two SNPs strongly associated with lung cancer on chromosome 15q25. Further genotyping in this region revealed many SNPs in tight linkage disequilibrium (LD) showing evidence of association. Six genes are located in this region including three nicotinic acetylcholine receptor subunits (CHRNA5, CHRNA3, and CHRNB4). Interestingly, no appreciable variation in the risk was found across smoking categories or histologic subtypes of lung cancer. In a second GWAS, a SNP within the CHRNA3gene was strongly associated with smoking quantity and nicotine dependence (15). The same SNP was also strongly associated with lung cancer. The results suggest that the variant on chromosome 15q25 confers risk of lung cancer through its effect on tobacco addiction.
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Equivalence of the Mediation, Confounding and Suppression Effect
March 31st, 2019Mediation (statistics) – Wikipedia
March 31st, 2019Cites the classic paper:
Baron, R. M. and Kenny, D. A. (1986) “The Moderator-Mediator Variable Distinction in Social Psychological Research – Conceptual, Strategic, and Statistical Considerations”, Journal of Personality and Social Psychology, Vol. 51(6), pp. 1173–1182.
https://en.wikipedia.org/wiki/Mediation_(statistics)
Introduction to Mediation Analysis | University of Virginia Library Research Data Services + Sciences
March 31st, 2019https://data.library.virginia.edu/introduction-to-mediation-analysis/
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To analyze mediation:
1. Follow Baron & Kenny’s steps
2. Use either the Sobel test or bootstrapping for significance testing. “]]