linkstream2 microblog

Sequence of events in prostate #cancer, by @MarkARubin1
http://www.Nature.com/articles/d41586-018-06029-5 Discusses the high prevalence of AR-enhancer amplifications in recent studies
QT:{{”
“Quigley and colleagues performed whole-genome sequencing of 101 samples of metastatic, castration-resistant prostate-cancer tissue obtained from previous studies11,12. The most frequently altered genomic site identified was the AR-enhancer region, which was amplified in 81% of samples. The high prevalence of this type of amplification is notable because enhancer amplifications identified so far for other cancer types generally arise at much lower
frequency13–16. Moreover, the high prevalence of this AR-enhancer amplification in the data presented by Viswanathan and Quigley contrasts with its occurrence in only 1 of 54 previously published whole-genome sequences of prostate-cancer samples obtained before clinical treatment had commenced17.”
“}}

Mind control as a guide for the mind | Nature Human Behaviour

https://www.nature.com/articles/s41562-017-0119

Modeling RNA Secondary Structure with Sequence Comparison &
Experimental Mapping Data
https://www.Cell.com/biophysj/fulltext/S0006-3495(17)30689-6 combines TurboFold sec. structure prediction w/ results of SHAPE assays

Zhen Tan
Gaurav Sharma
David H. Mathews

Open Archive Published:July 20, 2017
DOI:https://doi.org/10.1016/j.bpj.2017.06.039

Addressing the minimum fleet problem in on-demand urban mobility by @mmvazifeh, @stevenstrogatz et al.
https://www.Nature.com/articles/s41586-018-0095-1 Solved by putting taxis & their riders into a large #network

Muons: the little-known particles helping to probe the impenetrable, via @NaturePodcast https://www.Nature.com/articles/d41586-018-05254-2 Using “muography” to see into the ground, beneath volcanos & into pyramids

https://www.nature.com/articles/s41586-018-0409-3
QT:{{”
“… comprehensive genomic characterization of 27 strains of the common breast cancer cell line MCF7 uncovered rapid genetic
diversification. Similar results were obtained with multiple strains of 13 additional cell lines.
“}}

quite relevant
https://www.nature.com/articles/nmeth.4534

Resolving systematic errors in widely used enhancer activity assays in human cells

Felix Muerdter
, Łukasz M Boryń
, Ashley R Woodfin
, Christoph Neumayr
, Martina Rath
, Muhammad A Zabidi
, Michaela Pagani
, Vanja Haberle
, Tomáš Kazmar
, Rui R Catarino
, Katharina Schernhuber
, Cosmas D Arnold
& Alexander Stark

Nature Methods volume 15, pages141–149 (2018)

Don’t quote me: reverse identification of research participants in social media studies

John W. Ayers,
Theodore L. Caputi,
Camille Nebeker &
Mark Dredze

npj Digital Medicine
volume 1, Article number: 30 (2018)

https://www.nature.com/articles/s41746-018-0036-2

Induced Structural Disorder as a Molecular Mechanism for Enzyme Dysfunction in Phosphoglucomutase 1 Deficiency – ScienceDirect https://www.sciencedirect.com/science/article/pii/S0022283616001625

Perspective | OPEN | Published: 23 July 2018

Responsible sharing of biomedical data and biospecimens via the “Automatable Discovery and Access Matrix” (ADA-M)

J. Patrick Woolley,
Emily Kirby,
Josh Leslie,
Francis Jeanson,
Moran N. Cabili,
Gregory Rushton,
James G. Hazard,
Vagelis Ladas,
Colin D. Veal,
Spencer J. Gibson,
Anne-Marie Tassé,
Stephanie O. M. Dyke,
Clara Gaff,
Adrian Thorogood,
Bartha Maria Knoppers,
John Wilbanks &
Anthony J. Brookes

npj Genomic Medicinevolume 3, Article number: 17 (2018) | Download Citation

new paper in Nature Genomic Medicine:
https://www.nature.com/articles/s41525-018-0057-4