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Neutral genomic regions refine models of recent rapid human population growth

Elodie Gazave, Li Ma, Diana Chang, Alex Coventry, Feng Gao, Donna Muzny, Eric Boerwinkle, Richard A. Gibbs, Charles F. Sing, Andrew G. Clark, and Alon Keinan

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Recent rapid growth of human populations predicts that a large number of genetic variants in populations today are very rare, i.e., appear in a small number of individuals. This effect is similar to that of purifying selection, which drives deleterious alleles to become rarer. “}}

pos. sel. from 1000G phase 1

http://www.cell.com/retrieve/pii/S0092867413000871
Cell, Volume 152, Issue 4, 703-713, 14 February 2013
Copyright © 2013 Elsevier Inc. All rights reserved.
10.1016/j.cell.2013.01.035
Sharon R. Grossman,Kristian G. Andersen,Ilya Shlyakhter,Shervin Tabrizi,Sarah Winnicki,Angela Yen,Daniel J. Park,Dustin
Griesemer,Elinor K. Karlsson,Sunny H. Wong,Moran Cabili,Richard A. Adegbola,Rameshwar N.K. Bamezai,Adrian V.S. Hill,Fredrik O.
Vannberg,John L. Rinn,1000 Genomes Project,Eric S. Lander,Stephen F. Schaffner,Pardis C. Sabeti