linkstream2 microblog

TWAS of 229k women identifies new candidate susceptibility genes for breast cancer https://www.Nature.com/articles/s41588-018-0132-x Metascan approach. Derive model for imputing transcriptome from #GTEx & validate against TCGA. Application to BCAC.

Genome-wide prediction & functional characterization of the genetic basis of autism spectrum disorder, by @OlgaTroyanskaya lab
https://www.Nature.com/articles/nn.4353 Intersected candidate #ASD genes w/ #BrainSpan gene expression to find a pre-natal signal for the disease

Liked Tweets

https://docs.google.com/spreadsheets/d/e/2PACX-1vRRXndiFoAnxu5A6NThwRBwcWhKuvShUtjL-ol0LE3NfVMW7KC_hC17-512LmJhsMAeZIPm4beRVtIa/pubhtml

My talk

http://lectures.gersteinlab.org/summary/RADAR-Annot-prioritization-var-20180708-i0ismb18/

Links

https://linkstream2.gerstein.info/tag/i0ismb18

Creation & selection of mutations resistant to a #GeneDrive over mult. generations in the malaria mosquito
http://journals.PLoS.org/plosgenetics/article?id=10.1371/journal.pgen.1007039 Indels created by #NHEJ-based repair of DS breaks give rise to resistance (probably resulting from mis-matches due to
micro-homologies near breakpts)

Creation & selection of mutations resistant to a #GeneDrive over mult. generations in the malaria mosquito
http://journals.PLoS.org/plosgenetics/article?id=10.1371/journal.pgen.1007039 Indels created by #NHEJ-based repair of DS breaks give rise to resistance (probably resulting from mis-matches due to
micro-homologies near breakpts)

https://linkstream2.gerstein.info/tag/talk20180606/
https://twitter.com/MarkGerstein/status/1004566413036617728

https://linkstream2.gerstein.info/tag/talk20180606/
https://twitter.com/MarkGerstein/status/1004566413036617728

Alternative evolutionary histories in the sequence space of an ancient protein https://www.Nature.com/articles/nature23902 Great viz of different potential but not necessarily realized evolutionary trajectories. Quite relevant for molecular #evolution & #pseudogenes

Susceptibility of brain atrophy to TRIB3 in #Alzheimer’s disease, evidence from functional prioritization in imaging genetics
http://www.PNAS.org/content/115/12/3162.long Nice connection of developing phenotypes from #imaging, combined w. simple polygenic scores from genotypes

Genome-Scale Signatures of Gene Interaction from #CompoundScreens Predict…Efficacy of Targeted Cancer Therapies
https://www.ScienceDirect.com/science/article/pii/S2405471218300097 How to find drug combos: Find expression response profiles associated w/ a drug target. A synergistic drug might change profiles similarly