Posts Tagged ‘mynotes0mg’

Genome-wide prediction and functional characterization of the genetic basis of autism spectrum disorder | Nature Neuroscience

Friday, July 27th, 2018

Genome-wide prediction & functional characterization of the genetic basis of autism spectrum disorder, by @OlgaTroyanskaya lab
https://www.Nature.com/articles/nn.4353 Intersected candidate #ASD genes w/ #BrainSpan gene expression to find a pre-natal signal for the disease

My notes from ISMB 2018 – i0ismb18

Sunday, July 15th, 2018

Liked Tweets

https://docs.google.com/spreadsheets/d/e/2PACX-1vRRXndiFoAnxu5A6NThwRBwcWhKuvShUtjL-ol0LE3NfVMW7KC_hC17-512LmJhsMAeZIPm4beRVtIa/pubhtml

My talk

http://lectures.gersteinlab.org/summary/RADAR-Annot-prioritization-var-20180708-i0ismb18/

Links

https://linkstream2.gerstein.info/tag/i0ismb18

The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito

Friday, June 29th, 2018

Creation & selection of mutations resistant to a #GeneDrive over mult. generations in the malaria mosquito
http://journals.PLoS.org/plosgenetics/article?id=10.1371/journal.pgen.1007039 Indels created by #NHEJ-based repair of DS breaks give rise to resistance (probably resulting from mis-matches due to
micro-homologies near breakpts)

The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito

Friday, June 29th, 2018

Creation & selection of mutations resistant to a #GeneDrive over mult. generations in the malaria mosquito
http://journals.PLoS.org/plosgenetics/article?id=10.1371/journal.pgen.1007039 Indels created by #NHEJ-based repair of DS breaks give rise to resistance (probably resulting from mis-matches due to
micro-homologies near breakpts)

Today: Jason Moore, Computational Biology and Bioinformatics speaker, 6-6-18 in BML Auditorium at 4 pm

Friday, June 8th, 2018

https://linkstream2.gerstein.info/tag/talk20180606/
https://twitter.com/MarkGerstein/status/1004566413036617728

Today: Jason Moore, Computational Biology and Bioinformatics speaker, 6-6-18 in BML Auditorium at 4 pm

Friday, June 8th, 2018

https://linkstream2.gerstein.info/tag/talk20180606/
https://twitter.com/MarkGerstein/status/1004566413036617728

Papers for Journal Club

Thursday, June 7th, 2018

Alternative evolutionary histories in the sequence space of an ancient protein https://www.Nature.com/articles/nature23902 Great viz of different potential but not necessarily realized evolutionary trajectories. Quite relevant for molecular #evolution & #pseudogenes

Paper for Journal Club Tomorrow

Tuesday, May 22nd, 2018

Susceptibility of brain atrophy to TRIB3 in #Alzheimer’s disease, evidence from functional prioritization in imaging genetics
http://www.PNAS.org/content/115/12/3162.long Nice connection of developing phenotypes from #imaging, combined w. simple polygenic scores from genotypes

Genome-Scale Signatures of Gene Interaction from Compound Screens Predict Clinical Efficacy of Targeted Cancer Therapies – ScienceDirect

Sunday, April 29th, 2018

Genome-Scale Signatures of Gene Interaction from #CompoundScreens Predict…Efficacy of Targeted Cancer Therapies
https://www.ScienceDirect.com/science/article/pii/S2405471218300097 How to find drug combos: Find expression response profiles associated w/ a drug target. A synergistic drug might change profiles similarly

Fast, scalable prediction of deleterious noncoding variants from functional and population genomic data | Nature Genetics

Monday, March 19th, 2018

Fast, scalable prediction of deleterious #noncoding variants from functional & population genomic data
https://www.Nature.com/articles/ng.3810 LINSIGHT, by @ASiepel et al., combines DNAse & conservation information

Yi-Fei Huang, Brad Gulko & Adam Siepel
Nature Genetics 49, 618–624 (2017)
doi:10.1038/ng.3810
Published online:
13 March 2017