Posts Tagged ‘cancer’

Breaking Into The Brain | Chemical & Engineering News

Friday, September 22nd, 2017

Breaking Into the #Brain Contrasts potential for drug discovery in neuro-diseases v #cancer (which is “easier”)

interesting brain v cancer contrast

Whole-genome landscapes of major melanoma subtypes : Nature : Nature Research

Tuesday, September 5th, 2017

Hayward, Nicholas K., et al. "Whole-genome landscapes of major melanoma subtypes." Nature 545.7653 (2017): 175-180.

Whole-genome landscapes of…#melanoma subtypes Sun-exposed cutaneous w. many C>T SNVs v acral/mucosal w. many SVs

Naked mole rats: Can they help us cure cancer? – Slate Magazine

Tuesday, August 1st, 2017

Naked mole rats: Can they help..cure cancer? Live >6x longer than C57BL/6 & have “insectile” queen-domimated society

FYI – Personalized Medicine: Redefining Cancer Treatment

Monday, July 3rd, 2017

A Big Bang model of human colorectal tumor growth : Nature Genetics : Nature Research

Wednesday, June 7th, 2017

Big Bang model of…tumor growth, v. slow #evolution under selection #Cancer is born w/ key mutations all there

Andrea Sottoriva,
Haeyoun Kang,
Zhicheng Ma,
Trevor A Graham,
Matthew P Salomon,
Junsong Zhao,
Paul Marjoram,
Kimberly Siegmund,
Michael F Press,
Darryl Shibata
& Christina Curtis

Nature Genetics 47, 209–216 (2015) doi:10.1038/ng.3214

Cell Signaling by Receptor Tyrosine Kinases: Cell

Saturday, May 20th, 2017

[category scilit]

Cell signaling by #RTKs Nice 1st fig showing 20 sub-families and architecture of extra- & intra- cellular domains

Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution: Cell

Sunday, February 5th, 2017

Temporal Collateral Sensitivity in Tumor…Evolution Drug-fitness landscape illuminates transiently vulnerable state

Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution

Boyang Zhao
Joseph C. Sedlak
Raja Srinivas
Pau Creixell
Justin R. Pritchard
Bruce Tidor
Douglas A. Lauffenburger
Michael T. Hemann

Why Elephants Don’t Get Cancer—and What That Means for Humans

Saturday, December 17th, 2016

Why Elephants Don’t Get Cancer – many TP53 copies Result of #Peto’s Paradox: More cells don’t lead to more disease
see dog species

Protein-structure-guided discovery of functional mutations across 19 cancer types : Nature Genetics : Nature Research

Sunday, December 11th, 2016

Protein-structure-guided discovery of functional mutations across 19 #cancer types Cancer3D relates SNVs to drugs


Friday, October 7th, 2016