TWAS of 229k women identifies new candidate susceptibility genes for breast cancer https://www.Nature.com/articles/s41588-018-0132-x Metascan approach. Derive model for imputing transcriptome from #GTEx & validate against TCGA. Application to BCAC.
Genome-wide prediction & functional characterization of the genetic basis of autism spectrum disorder, by @OlgaTroyanskaya lab
https://www.Nature.com/articles/nn.4353 Intersected candidate #ASD genes w/ #BrainSpan gene expression to find a pre-natal signal for the disease
https://www.biorxiv.org/content/early/2017/10/15/203380
Leveraging molecular QTL to understand the genetic architecture of diseases and complex traits
Farhad Hormozdiari, Steven Gazal, Bryce van de Geijn, Hilary Finucane, Chelsea J.-T. Ju, Po-Ru Loh, Armin Schoech, Yakir Reshef, Xuanyao Liu, Luke O’Connor, Alexander Gusev, Eleazar Eskin, Alkes Price
doi: https://doi.org/10.1101/203380
https://www.nature.com/articles/s41588-018-0148-2
Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits
Farhad Hormozdiari,
Steven Gazal,
Bryce van de Geijn,
Hilary K. Finucane,
Chelsea J.-T. Ju,
Po-Ru Loh,
Armin Schoech,
Yakir Reshef,
Xuanyao Liu,
Luke O’Connor,
Alexander Gusev,
Eleazar Eskin &
Alkes L. Price
Pharmacogenomics of GPCR Drug Targets
https://doi.org/10.1016/j.cell.2017.11.033
Alexander S.Hauser
SreenivasChavali
IkuoMasuho
Leonie J.Jahn4
irill A.Martemyanov
David E.Gloriam
M. MadanBabu
vs
http://papers.gersteinlab.org/papers/db-integ-nsb/index.html it discusses using structure as a integrator in genomics .
Creation & selection of mutations resistant to a #GeneDrive over mult. generations in the malaria mosquito
http://journals.PLoS.org/plosgenetics/article?id=10.1371/journal.pgen.1007039 Indels created by #NHEJ-based repair of DS breaks give rise to resistance (probably resulting from mis-matches due to
micro-homologies near breakpts)
Creation & selection of mutations resistant to a #GeneDrive over mult. generations in the malaria mosquito
http://journals.PLoS.org/plosgenetics/article?id=10.1371/journal.pgen.1007039 Indels created by #NHEJ-based repair of DS breaks give rise to resistance (probably resulting from mis-matches due to
micro-homologies near breakpts)