linkstream2 microblog

16 Neuronal subtypes & [inter-regional] diversity revealed by [#singlecell]-nucleus RNAseq of…the brain
http://science.sciencemag.org/content/352/6293/1586.long

Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain.
Lake BB, Ai R, Kaeser GE, Salathia NS, Yung YC, Liu R, Wildberg A, Gao D, Fung HL, Chen S, Vijayaraghavan R, Wong J, Chen A, Sheng X, Kaper F, Shen R, Ronaghi M, Fan JB, Wang W, Chun J, Zhang K.
Science. 2016 Jun 24;352(6293):1586-90. doi: 10.1126/science.aaf1204.

Gray cites Parallel Genome-wide Expression Profiling of Indiv. Cells
w. nL Droplets http://www.sciencedirect.com/science/article/pii/S0092867415005498 … Drop-seq via barcodes #ngsus16

Weiss cites RNAi-Based Logic Circuit for Identification of…Cancer Cells http://science.sciencemag.org/content/333/6047/1307 How to optimize via adding FFLs #NGSUS16

adding in FFL & FBL to get more selectivity

Zhang, Bin, Chris Gaiteri, Liviu-Gabriel Bodea, Zhi Wang, Joshua McElwee, Alexei A. Podtelezhnikov, Chunsheng Zhang et al. "Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer’s disease." Cell 153, no. 3 (2013): 707-720.

Integrated systems approach identifies genetic…#networks in…Alzheimer’s http://www.Cell.com/cell/abstract/S0092-8674(13)00387-5 Determining causality from co-expression

Elucidating Molecular Motion (compatible w. #NMR relaxation times) through…Filters of Energy-Minimized…Ensembles
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983377

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132735

HTP discovery of novel developmental #phenotypes
http://www.nature.com/nature/journal/v537/n7621/full/nature19356.html New list of essential genes for the mouse, upping number to ~2900

high mutational burden predicts responsive patients

http://science.sciencemag.org/content/348/6230/124.long

ELMER

https://genomebiology.biomedcentral.com/articles/10.1186/s13059-015-0668-3

http://www.nejm.org/doi/full/10.1056/NEJMp1508811