linkstream2 microblog

ES cell

https://en.wikipedia.org/wiki/Embryonic_stem_cell

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Allis is best known for deciphering regulatory mechanisms that impinge upon the fundamental repeating unit of chromatin and for identifying the responsible enzyme systems that govern the covalent modifications of histone proteins, the principal components that organize chromatin. Allis discovered the critical link, through histone
acetyltransferase-containing transcriptional coactivators, between targeted histone acetylation and gene-specific transcriptional activation.
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His mod discoverer

https://en.wikipedia.org/wiki/Charles_David_Allis

X-ist & M Lyon & calico cats

https://en.wikipedia.org/wiki/X-inactivation

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Sir John Bertrand Gurdon FRS FMedSci (born 2 October 1933), is an English developmental biologist. He is best known for his pioneering research in nuclear transplantation[2][3][4] and cloning.[1][5][6][7] He was awarded the Lasker Award in 2009. In 2012, he and Shinya Yamanaka were awarded the Nobel Prize for Physiology or Medicine for the discovery that mature cells can be converted to stem cells.[8]

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https://en.wikipedia.org/wiki/John_Gurdon

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Epigenetic landscape

Waddington’s epigenetic landscape is a metaphor for how gene regulation modulates development.[10] Among other metaphors, Waddington asks us to imagine a number of marbles rolling down a hill.[11] The marbles will compete for the grooves on the slope, and come to rest at the lowest points. These points represent the eventual cell fates, that is, tissue types. Waddington coined the term chreode to represent this cellular developmental process. This idea was actually based on experiment: Waddington found that one effect of mutation (which could modulate the epigenetic landscape) was to affect how cells differentiated. He also showed how mutation could affect the landscape and used this metaphor in his discussions on evolution—he was the first person to emphasise that evolution mainly occurred through mutations that affected developmental anatomy.

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https://en.wikipedia.org/wiki/C._H._Waddington

What Dead Pigs Can’t Teach Us About @CSI_CBS
http://www.nytimes.com/2016/06/14/science/forensic-science-body-farm.html Wonder what this tells us about RIN? #RNAseq

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Novelty seeking
Despite early findings of an association between the DRD4 48bp VNTR and novelty seeking (a characteristic of exploratory and excitable people),[19][20] a 2008 meta-analysis compared 36 published studies of novelty seeking and the polymorphism and found no effect. The meta-analysis of 11 studies did find that another polymorphism in the gene, the -521C/T, showed an association with novelty seeking.[12] While human results are controversial, an increasing body of animal evidence has linked DRD4 variants with novelty seeking,
e.g.,,,[21][22][23][24][25] and new evidence suggests that human encroachment may exert selection pressure in favor of DRD4 variants associated with novelty seeking.[26] Novelty-seeking behavior is probably mediated by several genes, and the variance attributable to DRD4 by itself is not particularly large.[citation needed]
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https://en.wikipedia.org/wiki/Dopamine_receptor_D4

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Xq28 is a chromosome band and genetic marker situated at the tip of the X chromosome which has been studied since at least 1980.[1] The band contains three distinct regions, totaling about 8 Mbp of genetic information.[2] The marker came to the public eye in 1993 when studies by Dean Hamer and others indicated a link between the Xq28 marker and male sexual orientation.[3]
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https://en.wikipedia.org/wiki/Xq28

https://en.wikipedia.org/wiki/Dean_Hamer

SRY

https://en.wikipedia.org/wiki/Testis_determining_factor