Archive for September, 2017
Protein Structural Memory Influences Ligand Binding Mode(s) and Unbinding Rates – Journal of Chemical Theory and Computation (ACS Publications)
Tuesday, September 5th, 2017Structural Memory Influences Ligand-Binding Mode http://pubs.ACS.org/doi/abs/10.1021/acs.jctc.5b01052 Rearrangement of #solvation layer is ~100x slower than unbinding
J Chem Theory Comput. 2016 Mar 8;12(3):1393-9. doi:
10.1021/acs.jctc.5b01052. Epub 2016 Feb 3.
Xu M, Caflisch A, Hamm P.
Whole-genome landscapes of major melanoma subtypes : Nature : Nature Research
Tuesday, September 5th, 2017Hayward, Nicholas K., et al. "Whole-genome landscapes of major melanoma subtypes." Nature 545.7653 (2017): 175-180.
Whole-genome landscapes of…#melanoma subtypes http://www.Nature.com/nature/journal/vaop/ncurrent/full/nature22071.html Sun-exposed cutaneous w. many C>T SNVs v acral/mucosal w. many SVs
JOE & THE JUICE – 993 Lexington Avenue
Monday, September 4th, 2017https://www.joejuice.com/stores/usa/nyc-993-lexington-avenue/open at 6a
no sparkling
crowded
Will These Tiny Devices Make Smartphones a Thing of the Past? | NBC News
Monday, September 4th, 2017Rev favor
Sunday, September 3rd, 2017Does evolution bring the same results no matter what? – The Washington Post
Sunday, September 3rd, 2017Julian Assange, a Man Without a Country
Sunday, September 3rd, 2017.@JulianAssange, man w/o a country
https://www.NewYorker.com/magazine/2017/08/21/julian-assange-a-man-without-a-country/amp Eisenhower: “If you can’t solve a problem, enlarge it.” Now applied to @WikiLeaks
QT:{{”
Dwight Eisenhower is said to have once declared, “If you can’t solve a problem, enlarge it.” Assange had taken a personal legal crisis and blown it up into an international incident: he had teleported himself from the mundane into the tragic realm. A number of WikiLeaks volunteers urged him to step down until
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There have been calls for his assassination, and for him to be given a Nobel Peace Prize. Assange often describes himself in simple terms—as a fearless activist—but his character is complicated…
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How Driscoll’s Reinvented the Strawberry
Sunday, September 3rd, 2017QT:{{”
“The university, in a countersuit, accused Shaw of illegally breeding with the pipeline cultivars on behalf of his new company, while still employed by Davis. Entrusted with the “crown jewels,” the university contended, Shaw had attempted to destroy the public breeding program in order to enrich himself and his friends. Steven Knapp is a genomics expert, formerly of Monsanto, who was hired as Davis’s new breeder. When I talked to him by phone not long ago, he was apoplectic at what he perceived to be Shaw’s breach of loyalty.
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According to Frances Dillard, Driscoll’s global brand strategist and a veteran of Disney’s consumer-products division, berries are the produce category most associated with happiness. (Kale, in contrast, has a health-control, “me” focus.) On a slide that Dillard prepared, mapping psychographic associations with various fruits, strawberries floated between Freedom and Harmony, in a zone marked Extrovert, above a word cloud that read “Social, pleasure, joy, balance, conviviality, friendship, warmth, soft, natural, sharing.” (Blueberries vibed as status-oriented, demanding, and high-tech.)
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Driscoll’s senior vice-president and general counsel compared the company to its neighbors in Silicon Valley. “Growers are sort of like our manufacturing plants,” he said. “We make the inventions, they assemble it, and then we market it, so it’s not that dissimilar from Apple using someone else to do the manufacturing but they’ve made the invention and marketed the end product.” Like Apple, Driscoll’s guards its I.P. jealously.
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How Driscoll’s reinvented #strawberries
http://www.NewYorker.com/magazine/2017/08/21/how-driscolls-reinvented-the-strawberry Like Apple, invent & market, don’t manufacture. Now in #opendata v IP fight
On Your Bike, Watch Out for the Air – The New York Times
Sunday, September 3rd, 2017QT:{{"
“This elaborate gadgetry is part of a five-year study that aims to find out at what point the harm done by pollution to cyclists might outweigh the health benefits accrued from the exercise.
The strapped-on sensors measure levels of PM 2.5, the fine particulate matter that is about one-thirtieth the diameter of a human hair and thought to be particularly harmful to health. The tiny particles, including black carbon, the main component of soot, penetrate deep into the lungs and bloodstream and may lead to the development of respiratory illnesses like asthma and lung cancer. Even relatively short-term exposures can increase body-wide inflammation and boost the likelihood of strokes and heart attacks.
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A 2014 report issued by the New York City Health Department said that particulates in the air cause more than 2,000 premature deaths and 6,000 emergency room visits and hospitalizations each year.
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On Your #Bike, Watch Out for the Air https://www.NYTimes.com/2017/07/06/well/move/on-your-bike-watch-out-for-the-air.html City riding may bad for the lungs, involving inhaling air w/ high PM 2.5 levels