Posts Tagged ‘structint’

A structural transition in physical networks | Nature

Monday, August 12th, 2019

https://www.nature.com/articles/s41586-018-0726-6

A structural transition in physical networks

Nima Dehmamy, Soodabeh Milanlouei & Albert-László Barabási

Naturevolume 563, pages676–680 (2018)

Constructing structural networks of signaling pathways on the proteome scale

Saturday, September 6th, 2014

Structural networks of signaling pathways
http://www.sciencedirect.com/science/article/pii/S0959440X1200070X Prism on IL10 #networks, mapping on Cosmic, disrupting mutations as drivers

Dissecting Disease Inheritance Modes in a Three-Dimensional Protein Network Challenges the “Guilt-by-Asso ciation” Principle

Thursday, August 7th, 2014

Inheritance Modes in… #Network Challenges… Guilt-by-Association http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710751 #Diseases of recessive interface SNVs predictable

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710751/

surprisingly, no positional effects on LOF mutations … significant proportion of truncation alleles give rise to functional products

“guilt by assoc works”

signif. number dom mut give rise to func products

Exploring mechanisms of human disease through structurally resolved protein interactome networks

Saturday, July 19th, 2014

Mol Biosyst. Author manuscript; available in PMC Jul 1, 2014. Published in final edited form as:
Mol Biosyst. Jan 2014; 10(1): 9–17.
doi: 10.1039/c3mb70225a

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061614/

Three-dimensional reconstruction of protein networks provides insight into human genetic disease : Nature Biotechnology : Nature Publishing Group

Saturday, July 19th, 2014

http://www.nature.com/nbt/journal/v30/n2/full/nbt.2106.html

Dissecting Disease Inheritance Modes in a Three-Dimensional Protein Network Challenges the “Guilt-by-Asso ciation” Principle

Saturday, July 19th, 2014

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710751/

surprisingly, no positional effects on LOF mutations … significant proportion of truncation alleles give rise to functional products

“guilt by assoc works”

signif. number dom mut give rise to func products