linkstream2 microblog

https://en.wikipedia.org/wiki/Acromegaly

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The Yamna people or Yamnaya culture (traditionally known as the Pit Grave culture or Ochre Grave culture) was a late Copper Age to early Bronze Age culture of the region between the Southern Bug, Dniester and Ural rivers (the Pontic steppe), dating to 3300–2600 BC.[2] The Yamna culture is identified with the late Proto-Indo-Europeans, and is the strongest candidate for the Urheimat (homeland) of the
Proto-Indo-European language.
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They are also closely connected to later, Final Neolithic cultures which spread throughout Europe and Central Asia, especially the Corded Ware people, but also the Bell Beaker culture as well as the peoples of the Sintashta, Andronovo, and Srubna cultures. In these groups, several aspects of the Yamna culture (e.g., horse-riding, burial styles, and to some extent the pastoralist economy) are present. Genetic studies have also indicated that these populations derived large parts of their ancestry from the steppes.[3][6][7][8]
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https://en.m.wikipedia.org/wiki/Yamna_culture

https://en.wikipedia.org/wiki/Gravettian

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The Gravettians were hunter-gatherers who lived in a bitterly cold period of European prehistory, and Gravettian lifestyle was shaped by the climate.
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https://www.cell.com/ajhg/fulltext/S0002-9297(13)00289-9#%20

https://elifesciences.org/articles/45380

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This, however, requires accurate and unbiased estimation of the effects of all SNPs included in the score, which is difficult in a structured (non-homogeneous) population when environmental differences cannot be controlled. To see why this is a problem, consider the classic example of chopstick-eating skills (Lander and Schork, 1994). While there surely are genetic variants affecting our ability to handle chopsticks, most of the variation for this trait across the globe is due to environmental differences (cultural background), and a GWAS would mostly identify variants that had nothing to do with chopstick skills, but simply happened to differ in frequency between East Asia and the rest of the world.
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Sodium/potassium/calcium exchanger 5 (NCKX5), also known as solute carrier family 24 member 5 (SLC24A5), is a protein that in humans is encoded by the SLC24A5 gene that has a major influence on natural skin colour variation.[5] The NCKX5 protein is a member of the
potassium-dependent sodium/calcium exchanger family. Sequence variation in the SLC24A5 gene, particularly a non-synonymous SNP changing the amino acid at position 111 in NCKX5 from alanine to threonine, has been associated with differences in skin
pigmentation.[6]
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https://en.wikipedia.org/wiki/Sodium/potassium/calcium_exchanger_5

https://www.theverge.com/2017/10/9/16448412/neanderthal-stone-age-human-genes-dna-schizophrenia-cholesterol-hair-skin-loneliness

https://blog.23andme.com/ancestry/the-neanderthal-in-all-of-us/

ethnicity & diabetes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000712/

https://natureecoevocommunity.nature.com/users/192550-fernando-villanea/posts/41414-how-many-times-did-modern-humans-mate-with-neandertals