linkstream2 microblog

Published: 21 August 2019

Conserved cell types with divergent features in human versus mouse cortex

Rebecca D. Hodge, Trygve E. Bakken, Jeremy A. Miller, Kimberly A. Smith, Eliza R. Barkan, Lucas T. Graybuck, Jennie L. Close, Brian Long, Nelson Johansen, Osnat Penn, Zizhen Yao, Jeroen Eggermont, Thomas Höllt, Boaz P. Levi, Soraya I. Shehata, Brian Aevermann, Allison Beller, Darren Bertagnolli, Krissy Brouner, Tamara Casper, Charles Cobbs, Rachel Dalley, Nick Dee, Song-Lin Ding, Richard G. Ellenbogen, Olivia Fong, Emma Garren, Jeff Goldy, Ryder P. Gwinn, Daniel Hirschstein, C. Dirk Keene, Mohamed Keshk, Andrew L. Ko, Kanan Lathia, Ahmed Mahfouz, Zoe Maltzer, Medea McGraw, Thuc Nghi Nguyen, Julie Nyhus, Jeffrey G. Ojemann, Aaron Oldre, Sheana Parry, Shannon Reynolds, Christine Rimorin, Nadiya V. Shapovalova, Saroja
Somasundaram, Aaron Szafer, Elliot R. Thomsen, Michael Tieu, Gerald Quon, Richard H. Scheuermann, Rafael Yuste, Susan M. Sunkin, Boudewijn Lelieveldt, David Feng, Lydia Ng, Amy Bernard, Michael Hawrylycz, John W. Phillips, Bosiljka Tasic, Hongkui Zeng, Allan R. Jones, Christof Koch & Ed S. Lein

https://www.nature.com/articles/s41586-019-1506-7

Meet Ryan, the seven-year-old YouTuber who made £17.3m in a year
https://www.theGuardian.com/technology/shortcuts/2018/dec/04/meet-ryan-the-seven-year-old-youtuber-who-made-173m-in-a-year What will he make when he turns 20!

Meet Ryan, the seven-year-old YouTuber who made £17.3m in a year | Technology | The Guardian
www.theguardian.com
Name: Ryan. Age: Seven. Value: £17.3m. It’s wrong to hate a child, isn’t it? Yes! Of course it is. Especially if you hate them for having more money than you. Let’s end this line of inquiry …

https://www.theguardian.com/technology/shortcuts/2018/dec/04/meet-ryan-the-seven-year-old-youtuber-who-made-173m-in-a-year

Meet Ryan, the seven-year-old YouTuber who made £17.3m in a year | Technology | The Guardian
www.theguardian.com
Name: Ryan. Age: Seven. Value: £17.3m. It’s wrong to hate a child, isn’t it? Yes! Of course it is. Especially if you hate them for having more money than you. Let’s end this line of inquiry …

http://www.sciencemag.org/news/2016/03/alzheimer-s-may-be-caused-haywire-immune-system-eating-brain-connections

Alzheimer’s may be caused by haywire immune system eating brain connections Study targets new mechanism in fight against cognitive decline

A #circadian gene-expr atlas in mammals by @jbhclock lab
http://www.PNAS.org/content/111/45/16219.abstract 43% of genes have a daily rhythm in at least 1 tissue [1/2]

.@jbhclock Fewest circadian genes in brain; most in liver. Perhaps this more reflects daily feeding cycle than true light-dark cycle? [2/2]

A circadian gene expression atlas in mammals: Implications for biology and medicine

Ray Zhanga,1,
Nicholas F. Lahensa,1,
Heather I. Ballancea,
Michael E. Hughesb,2, and
John B. Hogenescha,2

* Interestingly brain regions have the fewest circ genes(only ~3%), liver has most

* Diseases assoc with circadian genes correlate with NIH funding

* Genes can have up to a 6-hour phase diff. Between diff. organs (eg Vegfa betw. Heart & fat)

* 56 of the top 100 drugs incl. Top 7, targeted the product of a circadian gene. Related to the half-life of drugs.

* Could the liver genes be more reflective of feeding rhythm rather than true circadian clock.