linkstream2 microblog

$GOOG Is Giving Away AI That Can Build Your Genome Seq. https://Research.GoogleBlog.com/2017/12/deepvariant-highly-accurate-genomes.html + https://www.Wired.com/story/google-is-giving-away-ai-that-can-build-your-genome-sequence GATK creators now doing a tensor-flow version. Release sounded a bit like IBM unveiling Deep Blue decades ago: “Today, we announce…DeepVariant, a #DeepLearning tech…"

Steven Salzberg’s response to deep variant:
https://www.forbes.com/sites/stevensalzberg/2017/12/11/no-googles-new-ai-cant-build-your-genome-sequence/#5953db7b5774

QT:{{"On Monday, Google released a tool called DeepVariant that uses deep learning—the machine learning technique that now dominates AI—to identify all the mutations that an individual inherits from their parents.1 Modeled loosely on the networks of neurons in the human brain, these massive mathematical models have learned how to do things like identify faces posted to your Facebook news feed, transcribe your inane requests to Siri, and even fight internet trolls. And now, engineers at Google Brain and Verily (Alphabet’s life sciences spin-off) have taught one to take raw sequencing data and line up the billions of As, Ts, Cs, and Gs that make you you.”
"}}

Google Is Giving Away AI That Can Build Your Genome Sequence
https://www.wired.com/story/google-is-giving-away-ai-that-can-build-your-genome-sequence/

Behind the Murdochs’ Sale Talks: Scale, Price & Family Dynamics
https://www.wsj.com/articles/behind-the-murdochs-sale-talks-scale-price-and-family-dynamics-1512521082 Walking on eggshells: @WSJ reporting on a family that owns the paper & its plans to sell part of its empire

Useful
https://www.electricitylocal.com/states/connecticut/new-haven/

Batch Cloud Data Transfer for @AWScloud
https://AWS.amazon.com/snowball & https://AWS.amazon.com/snowmobile Snail mail trumps email for really large data. Interesting to calculate effective transfer rates as compared “Ethernet.” Surprised that I couldn’t find even crude estimates.

https://www.youtube.com/watch?v=6DLWNdjqPC8

https://www.nytimes.com/2017/11/24/your-money/seasonal-business.html

Evogeneao: The Tree of Life
https://www.evogeneao.com/explore/tree-of-life-explorer Nice web tool. Particularly good for interactively #visualizing human #evolution relative to that of other species

QT:{{”
• Find 3.8 Å resolution cryo-EM structure of the ∼200 kDa magnesium channel CorA • Mg2+-free CorA exhibits dramatic loss of symmetry in the cytoplasmic domain …
• Inter-subunit Mg2+ is important for stabilizing the closed state of CorA “}}

#CryoEM Structures of the Mg++ Channel CorA Reveal Symmetry Break upon Gating https://www.ScienceDirect.com/science/article/pii/S0092867415017195 In closed conformation: 5 identical subunits arranged tightly around 5-fold axis & pore. In open: they lose bridging ions & open to differing degrees with helix-hinging motions.

Matthies D1, Dalmas O2, Borgnia MJ1, Dominik PK2, Merk A1, Rao P1, Reddy BG2, Islam S2, Bartesaghi A1, Perozo E3, Subramaniam S4. Cell. 2016 Feb 11;164(4):747-56. doi: 10.1016/j.cell.2015.12.055.

”
Box 1 of the following paper has a nice definition for differential privacy in genomics sense (phenotypic differential privacy): http://www.cell.com/cell-systems/fulltext/S2405-4712(16)30121-1 “

https://www.nytimes.com/2017/11/24/your-money/seasonal-business.html