Developmental dynamics… of random monoallelic gene expression. #RNAseq on 100s of instances without causative SNPs
An analysis of differentiated cell lines.
http://www.cell.com/developmental-cell/abstract/S1534-5807(14)00057-4
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We discovered abundant (12 to 24%) monoallelic expression of autosomal genes and that expression of the two alleles occurs independently. The monoallelic expression appeared random and dynamic because there was considerable variation among closely related embryonic cells. Similar patterns of monoallelic expression were observed in mature cells. Our allelic expression analysis also demonstrates the de novo inactivation of the paternal X chromosome.
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http://www.nature.com/msb/journal/v8/n1/pdf/msb201234.pdf
Quantitative measurement of allele-specific protein expression in a diploid yeast hybrid by LC-MS