Archive for December, 2017

The Man Who Knows Whether Any Startup Will Live or Die

Monday, December 4th, 2017

The Man Who Knows Whether Any Startup Will Live or Die
https://www.Wired.com/2015/01/growth-science Quote: “You can’t trust the model until you get all the intuition out of it.” Not sure I agree!

QT:{{”
“Swapping out your drafty old windows for new energy efficient ones could save you a bundle in the long-term, but not everyone wants to spend the time and money to retrofit their entire home or office building. Indow Windows offers inserts that can improve efficiency without the cost or hassle of replacing the windows entirely. “Some other startups have tried this, and some of the big guys are trying to respond, but there’s a lot more innovation required to pull this off than most people suspect,” Thurston says. “In a very short timeframe Indow has zoomed up to become the market leader.”


His approach is based on turning various pieces of qualitative information—such as whether a company is a “first mover” or “fast follower” in a market—into quantitative data that he can plug into a spreadsheet. That requires a degree of human judgement, but this also requires a certain amount of rigor or consistency.

“You can’t trust the model until you get all the intuition out of it,” Thurston says. “The hard part of that is translating the qualification into yes or no questions,” he says. “How do you define the market? How do you define first mover?””

“}}

CVS Is Said to Agree to Buy Aetna, Reshaping Health Care Industry – The New York Times

Sunday, December 3rd, 2017

https://www.nytimes.com/2017/12/03/business/dealbook/cvs-is-said-to-agree-to-buy-aetna-reshaping-health-care-industry.html

What We Can Learn From the Second Life of Google Glass

Sunday, December 3rd, 2017

https://singularityhub.com/2017/11/26/what-we-can-learn-from-the-second-life-of-google-glass/

Evogeneao: The Tree of Life

Sunday, December 3rd, 2017

Evogeneao: The Tree of Life
https://www.evogeneao.com/explore/tree-of-life-explorer Nice web tool. Particularly good for interactively #visualizing human #evolution relative to that of other species

Winners and losers in the Senate GOP tax bill: A running list – The Washington Post

Saturday, December 2nd, 2017

https://www.washingtonpost.com/news/wonk/wp/2017/12/01/winners-and-losers-in-the-senate-gop-tax-bill-a-running-list/

Sent from my iPad

Deep learning and Google Street View to estimate the demographic makeup of neighborhoods across the United States

Friday, December 1st, 2017

http://www.pnas.org/content/early/2017/11/27/1700035114.abstract

Cryo-EM Structures of the Magnesium Channel CorA Reveal Symmetry Break upon Gating – ScienceDirect

Friday, December 1st, 2017

QT:{{”
• Find 3.8 Å resolution cryo-EM structure of the ∼200 kDa magnesium channel CorA • Mg2+-free CorA exhibits dramatic loss of symmetry in the cytoplasmic domain …
• Inter-subunit Mg2+ is important for stabilizing the closed state of CorA “}}

#CryoEM Structures of the Mg++ Channel CorA Reveal Symmetry Break upon Gating https://www.ScienceDirect.com/science/article/pii/S0092867415017195 In closed conformation: 5 identical subunits arranged tightly around 5-fold axis & pore. In open: they lose bridging ions & open to differing degrees with helix-hinging motions.

Matthies D1, Dalmas O2, Borgnia MJ1, Dominik PK2, Merk A1, Rao P1, Reddy BG2, Islam S2, Bartesaghi A1, Perozo E3, Subramaniam S4. Cell. 2016 Feb 11;164(4):747-56. doi: 10.1016/j.cell.2015.12.055.