AI for drug discovery – cyan
Saturday, July 1st, 2017‘Make Pharma Great Again with Artificial Intelligence: some Challenges’
‘Make Pharma Great Again with Artificial Intelligence: some Challenges’
FormBox: A Desktop…Former…Makes Beautiful Things, by @TeamMayku
https://www.KickStarter.com/projects/1094489804/formbox-a-desktop-vacuum-former-that-makes-beautif 3D printouts w/ chocolate & cement + ABS, PVC…
ice too
QT:{{”
“Acrylonitrile Butadiene Styrene ABS (the stuff Lego is made from) Polystyrene PS (Commonly found in: Product packaging)
Polycarbonate PC (Commonly found in: Drinks bottles)
Polypropylene PP (Commonly found in: Buckets, spades, chairs, everything!) Polyethylene (Commonly found in: sheet and foamed sheet)
PE (Commonly found in: Insulating cases, bottles)
Polyvinyl Chloride PVC (Commonly found in: straws, plastic pipes) Acrylic PMMA (Commonly found in: Light up signs)
PETg (Commonly found in: Food safe molds)
HIPS (Commonly found in: Disposable cups)”
“}}
Facebook, Free Expression & the Power of a Leak, by @MargotKaminski
https://www.NYTimes.com/2017/06/27/opinion/facebook-first-amendment-leaks-free-speech.html Internal company choices vs. the law
QT:{{”
“But there are also crucial distinctions. Where First Amendment law protects speech about public figures more than speech about private individuals, Facebook does the opposite. If a user calls for violence, however generic, against a head of state, Facebook deems that a credible threat against a “vulnerable person.” It’s fine to say, “I hope someone kills you.” It is not fine to say, “Somebody shoot Trump.” While the government cannot arrest you for saying it, Facebook will remove the post.
These differences are to be expected. Courts protect speech about public officials because the Constitution gives them the job of protecting fundamental individual rights in the name of social values like autonomy or democratic self-governance. Facebook probably constrains speech about public officials because as a large corporate actor with meaningful assets, it and other sites can be pressured into cooperation with governments.”
“}}
Genome-wide characterization of..promoters w…enhancer functions http://www.Nature.com/ng/journal/v49/n7/full/ng.3884.html Blurs distinction betw these, suggests flexibility
Genome-wide characterization of mammalian promoters with distal enhancer functions
Lan T M Dao,
Ariel O Galindo-Albarrán,
Jaime A Castro-Mondragon,
Charlotte Andrieu-Soler,
Alejandra Medina-Rivera,
Charbel Souaid,
Guillaume Charbonnier,
Aurélien Griffon,
Laurent Vanhille,
Tharshana Stephen,
Jaafar Alomairi,
David Martin,
Magali Torres,
Nicolas Fernandez,
Eric Soler,
Jacques van Helden,
Denis Puthier
& Salvatore Spicuglia
Promoting transcription over long distances
Rui R Catarino,
Christoph Neumayr
& Alexander Stark
Nature Genetics 49, 972–973 (2017) doi:10.1038/ng.3904
28 June 2017
http://www.nature.com/ng/journal/v49/n7/full/ng.3884.html
http://www.nature.com/ng/journal/v49/n7/full/ng.3904.html
QT:{{”
“Should we be surprised that promoters can function as enhancers—or better—that enhancers and promoter regions can overlap? Probably not: the habit of annotating different genomic regions with distinct labels ignores the fact that DNA sequences typically encode different genetic functions in a rather flexible manner. Enhancers and promoters are determined by the presence of short degenerate motifs, and even protein-coding regions display flexibility due to the degeneracy of the genetic code. Therefore, a single DNA sequence can encode different types of functions, including enhancer function of protein-coding regions or—as shown now—enhancer function of
promoters.”
“}}
https://en.wikipedia.org/wiki/Pectin
in apples