linkstream2 microblog

A Variant of the HTRA1 Gene Increases Susceptibility to Age-Related Macular Degeneration

Zhenglin Yang1,2,3,*,
Nicola J. Camp4,*,
Hui Sun5,
Zongzhong Tong1,2,
Daniel Gibbs1,2,
D. Joshua Cameron1,2,
Haoyu Chen1,2,
Yu Zhao1,2,
Erik Pearson1,2,
Xi Li1,2,
Jeremy Chien6,
Andrew DeWan7,
Jennifer Harmon1,2,
Paul S. Bernstein1,
Viji Shridhar6,
Norman A. Zabriskie1,
Josephine Hoh7,
Kimberly Howes1,
Kang Zhang1,2,†

http://science.sciencemag.org/content/314/5801/992

QT:{{”
Age-related macular degeneration results in blindness, and one major locus (HTRAX) accounts for approximately one-half of genetic cases. “}}
Should be HTRA1

http://ghr.nlm.nih.gov/condition/age-related-macular-degeneration

Similarity #network fusion for aggregating data types
http://www.nature.com/nmeth/journal/v11/n3/full/nmeth.2810.html Combines mRNA, miRNA & gene fusions to classify cancer subtypes http://compbio.cs.toronto.edu/SNF/SNF

.@emblEBI in ’16 via @ewanbirney
http://europepmc.org/articles/PMC4702932/ Seq DB growth stable w/ yearly doubling (post ~’08 spike) & EGA now faster than ENA

cite the data growth stats here:
http://europepmc.org/articles/PMC4702932/figure/F2/

Fig 2
– amt prvt data incr as for ncbi + arrays are falling now less than masspec – after a huge incr from ’07 to ’12 , now stab. at12-mo doubling

http://www.nature.com/ncomms/2015/150121/ncomms7033/full/ncomms7033.html

Julie Brind’Amour,
Sheng Liu,
Matthew Hudson,
Carol Chen,
Mohammad M. Karimi
& Matthew C. Lorincz

Nature Communications 6, Article number: 6033 doi:10.1038/ncomms7033

http://www.nature.com/neuro/journal/v19/n1/abs/nn.4181.html

Andrew E Jaffe,
Yuan Gao,
Amy Deep-Soboslay,
Ran Tao,
Thomas M Hyde,
Daniel R Weinberger
& Joel E Kleinman

Nature Neuroscience 19, 40–47 (2016) doi:10.1038/nn.4181

A man who recorded every detail of his life for 5 yrs
http://qz.com/519298/the-story-of-a-man-who-recorded-every-detail-of-his-life-for-five-years/ Interesting combo of hi-tech camera & low-tech written logbook

QT:{{”
“For example, the camera captured a meeting with a colleague in the office corridor, but that didn’t make it in to the log book. Or the log book captured a 30-minute task completed on the computer, but the camera missed that.

The result, as he had suspected, was that the combination was helping him capture more of his day. The log book allowed for reflection and the narrative camera added texture to the reflection.

The power of introspection

There is some scientific evidence of the benefits of Villarroel’s practice. “The experience is consistent with mindfulness practices, which have been shown to have great benefits,” Ronald Riggio, a psychologist at Claremont McKenna College, told Quartz. “The perception of time, however, is subjective.””
“}}

Alphabet passes Apple market cap http://www.cnbc.com/2016/02/01/google-passes-apple-as-most-valuable-company.html 4 largest now in tech ($GOOG $547B, $AAPL 529, $MSFT 425, $FB 326) w/ big oil at #5
QT:{{"
Shares of Alphabet opened nearly 3 percent higher Tuesday, pushing the
technology giant’s market capitalization past Apple to become the
world’s most valuable public company.

Alphabet has a market cap of $547.1 billion, higher than Apple’s
$529.3 billion as of 9:45 a.m. ET.

Apple’s massive market cap is still trailed by Microsoft ($425.7
billion),Facebook ($326.2 billion) and Exxon Mobil ($310.1 billion) to
round out the list of the world’s five biggest companies.
"}}

http://www.americanscientist.org/issues/id.16146,y.2014,no.2,content.true,page.1,css.print/issue.aspx

http://www.wsj.com/articles/do-this-one-hour-security-drill-5-steps-to-being-safer-online-1454528541

https://www.cs.cornell.edu/home/kleinber/networks-book/