linkstream2 microblog

Some quick thoughts after listening to first 9 episodes

“Will Musicians Survive in the Age of Free When the “Bottle” is worth more than the wine” – a great line & an observation that the spotify platform is worth more than its music . See also:
http://unsoundthemovie.com/

“Intent, Licenses and “Sweat of the Brow” – helpful discussion of copyright but it would have been nice to hear about copyleft & re-combining of artworks

“two letters and a number” – MP3.com was originally someone’s name. Robertson’s story how on how to be sued & wooed simultaneously

“so… Why does Liza Minnelli get paid when the Sex Pistols Stream?” – how to weight things (downloads or listeners) & various frauds based on this…

Can you Sell Something that Doesn’t Exist? – Superfans: would you rather collect unemployment or by the latest Doors album?

https://itunes.apple.com/us/podcast/21khz-the-art-of-money-in-music/id987160981

perhaps useful for workflow viz
https://www.mindmeister.com/

https://www.scribendi.com/

Interesting …..
http://www.spire.io/

http://www.newyorker.com/magazine/2015/11/23/the-trip-planners

http://mobile.nytimes.com/2015/12/30/business/economy/for-the-wealthiest-private-tax-system-saves-them-billions.html?_r=1&referer=https://www.google.com/

http://mobile.nytimes.com/blogs/well/2015/12/28/posture-affects-standing-and-not-just-the-physical-kind/?_r=0&referer=https://www.google.com/

http://www.makeuseof.com/tag/15-essential-chrome-extensions-google-drive/?utm_campaign=twitter&utm_medium=twitter&utm_source=twitter

http://www.scientificamerican.com/article/its-time-to-end-the-war-on-salt/

Tumor genome simulation w/ #crowdsourcing to benchmark…SNV detection http://www.nature.com/nmeth/journal/v12/n7/full/nmeth.3407.html Addresses lack of gold standards & privacy

Ewing, Houlahan…..Stuart, Boutros (2015) “Combining accurate
tumour genome simulation with crowd-sourcing to benchmark somatic
single nucleotide variant detection” Nature Methods 12(7):623-630
(PMID: 25984700)

A crowdsourced benchmark of somatic mutation detection algorithms was
introduced for the ICGC-TCGA DREAM challenge. This has the advantage
of dealing with the lack of gold standard data and the issue of
sharing private genomic data. All groups worked on three different
simulated tumor-normal pairs generated with BAMSurgeon, by directly
adding synthetic mutations to existing reads. An ensemble of
pipelines outperforms the best individual pipeline in all cases,
assessed on the basis of recall, precision and F-score.
Parameterization and genomic localization both have an effect on
pipeline performance, while characteristics of prediction errors
differed for most pipelines.