Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL
RUNX1 is most connected in TLX1 & 3 expr. net. It’s a tumor suppressor disabled by LOF mutations.
Rev. engineering…identifies RUNX1 as tumor suppressor in T-ALL http://www.nature.com/nm/journal/v18/n3/full/nm.2610.html It’s the most connected TF in the expression network
Nat Med. Author manuscript; available in PMC 2012 Sep 1.
Nat Med. 2012 Feb 26; 18(3): 436–440.
Published online 2012 Feb 26. doi: 10.1038/nm.2610
Giusy Della Gatta,1 Teresa Palomero,1,2 Arianne Perez-Garcia,1 Alberto Ambesi-Impiombato,1 Mukesh Bansal,3Zachary W. Carpenter,1 Kim De Keersmaecker,4,5 Xavier Sole,6,7 Luyao Xu,1 Elisabeth Paietta,8,9 Janis Racevskis,8,9Peter H Wiernik,8,9 Jacob M Rowe,10 Jules P Meijerink,11 Andrea Califano,1,3 and Adolfo A. Ferrando1,2,12