Archive for January, 2015
Critical Truths About Power Laws
Monday, January 12th, 2015End of cancer-genome project prompts rethink
Monday, January 12th, 2015Improve Collaborative Editing Of Office Files With Dropbox & Project Harmony
Monday, January 12th, 2015Improve Collaborative Editing Of #Office Files With Dropbox & Project Harmony http://www.makeuseof.com/tag/improve-collaborative-editing-office-files-dropbox-project-harmony Interesting alternative to #Google Docs
Variation in cancer risk among tissues can be explained by the number of stem cell divisions
Monday, January 12th, 2015Tomasetti & Volgenstein
Science 2 January 2015:
Vol. 347 no. 6217 pp. 78-81
DOI: 10.1126/science.1260825
It’s a correlation between aggressiveness, mutations and cell division http://www.sciencemag.org/content/347/6217/78
NEw paper using BrainSpan data
Monday, January 12th, 2015The discovery of integrated gene networks for autism and related disorders
Fereydoun Hormozdiari
Osnat Penn
Elhanan Borenstein
Evan E. Eichler
Published in Advance November 5, 2014, doi:10.1101/gr.178855.114 Genome Res. 2015. 25: 142-154
QT:{{”
Motivated by this observation, we have developed a novel method that simultaneously integrates information from both PPI and coexpression networks to identify highly connected modules in both types of networks that are also enriched in mutations in cases and not in controls. We call this method MAGI, short for merging affected genes into integrated networks. MAGI is based on a combinatorial
optimization algorithm that aims to maximize the number of mutations in the modules while accounting for gene length and distribution of putative LoF and missense mutations in cases and controls. MAGI is generic and can be applied to any disease, given a list of de novo mutations in cases and relevant coexpression information. Using neurodevelopmental RNA-seq data from the BrainSpan Atlas
(http://www.brainspan.org/), we have applied it to exome sequence data generated from ASD, ID, epilepsy, and schizophrenia, providing a comprehensive comparison of common and specific gene modules for these diseases.
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NOT-OD-15-032: Update: New Biographical Sketch Format Required for NIH and AHRQ Grant Applications Submitted for Due Dates on or After May 25, 2015
Sunday, January 11th, 2015Ageing does not have to bring poor health and frailty, say King’s College scientists – Telegraph
Sunday, January 11th, 2015They also served
Sunday, January 11th, 2015#Statisticians in World War II: They also served
http://www.economist.com/news/christmas-specials/21636589-how-statisticians-changed-war-and-war-changed-statistics-they-also-served Developed quality controls & sequential methods HT @stodden