Archive for May, 2014

Realities of data sharing using the genome wars as case study – an historical perspective and commentary

Monday, May 12th, 2014

Kevin Davies ‏@KevinADavies2m
Cool article on data sharing, Celera and the Genome Wars by veteran @Sciencemagazine editor Barbara Jasny … #OpenAccess

http://www.epjdatascience.com/content/pdf/epjds13.pdf

retroelement functional recruitment

Monday, May 12th, 2014

DUX4 binding to #retroelements creates promoters that are active… Highlights #chipseq binding sites in #repeats
http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1003947 http://www.ncbi.nlm.nih.gov/pubmed/?term=24278031
PLoS Genet. 2013 Nov;9(11):e1003947. doi:
10.1371/journal.pgen.1003947. Epub 2013 Nov 21.
DUX4 binding to retroelements creates promoters that are active in FSHD muscle and testis.
Young JM, Whiddon JL, Yao Z, Kasinathan B, Snider L, Geng LN, Balog J, Tawil R, van der Maarel SM, Tapscott SJ.

Searching for missing heritability: Designing rare variant association studies

Monday, May 12th, 2014

http://www.pnas.org/content/111/4/E455.long

“In particular, a well-powered RVAS (rare variant association study) should involve discovery sets with at least 25,000 cases, together with a substantial replication set.”

cell free DNA circulating for cancer

Monday, May 12th, 2014

NYT recently ran an article as well:
http://www.nytimes.com/2014/04/08/business/cancer-analysis-tools-circumvent-biopsies.html

http://www.nature.com/nm/journal/v20/n4/abs/nm.3511.html

An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage
http://www.nature.com/nm/journal/vaop/ncurrent/abs/nm.3519.html

http://stm.sciencemag.org/content/6/224/224ra24
http://www.nejm.org/doi/full/10.1056/NEJMoa1213261

http://stm.sciencemag.org/content/4/162/162ra154.full
DIAGNOSTICS: Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome Sequencing

Twitter data grants

Sunday, May 11th, 2014

https://blog.twitter.com/2014/introducing-twitter-data-grants

And now a video game for cancer genomics !

Sunday, May 11th, 2014

we can play in meetings, and tell people we are working on cancer research.
http://scienceblog.cancerresearchuk.org/2014/02/04/download-our-revolutionary-mobile-game-to-help-speed-up-cancer-research

Trek bikes I’ve used…

Sunday, May 11th, 2014

Works well with back rack + clips + water bottle holder. However, over-handlebar risk
http://www.trekbikes.com/us/en/bikes/road/fitness/fx/7_7_fx/ $2K

http://www.trekbikes.com/us/en/bikes/road/fitness/fx/7_5_fx/ $1K

more info on bikes:
https://delicious.com/mbgmbg/clust_trekbikes

18 Courses from Stanford, Wharton, Duke, Berkeley – AnalyticBridge

Sunday, May 11th, 2014

MT @KirkDBorne @analyticbridge 18 Courses from Stanford, Wharton, Duke, Berkeley… #DataScience #Analytics http://bit.ly/1ixpizD #teaching

http://www.analyticbridge.com/group/analyticscourses/forum/topics/18-courses-from-stanford-wharton-duke-berkeley

Should Healthy People Have Their Genomes Sequenced? – WSJ.com

Sunday, May 11th, 2014

http://online.wsj.com/news/articles/SB10000872396390443884104577645783975993656

A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites : Nature Communications : Nature Publishing Group

Sunday, May 11th, 2014

http://www.nature.com/ncomms/2014/140205/ncomms4216/full/ncomms4216.html Mentioned as a mechanism for “occasional presence of templated insertions.”