The tallest & shortest man in the world meet for a day
http://mashable.com/2014/11/13/tallest-shortest-man-record Great images illustrating the extent of human variation
Great @carlzimmer article on #mosaicism. However, its scale is much less than natural or cancer variation http://nyti.ms/15ymYlJ MT @darnelr
Might have been worth mentioning that the amount of somatic variation in healthy cells appears to be considerably less than the variation between people or between a tumor and normal genome.
http://www.nytimes.com/2013/09/17/science/dna-double-take.html
#Variation prefers the golden mean: Moderate selection involves many loci v weak & strong, few http://bit.ly/18MgU6p via @drbachinsky
Moderate selection, many loci; Weak or strong selection, few loci.
http://blogs.discovermagazine.com/gnxp/2013/09/distributed-variation-prefers-the-golden-mean/#.UjJTHmSG1MF
http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1003709#pgen-1003709-g006
This paper discusses gene intolerance score — very similar to depletion of common polymorphisms. They don’t analyze non-coding regions — this is using exome data only. Blue for tolerant and red for intolerant (see Figure 1) .
http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.2658.html Uses only CG data for variation, only TFBS data form ENCODE. QT:”the binding sites of several transcription factors show clear evidence of adaptation.”
Paper giving a conceptual framework to somatic mosaicism
http://www.ncbi.nlm.nih.gov/pubmed/21441354
QT:”
By performing in silico whole genome analysis, we demonstrate that both the number of miRNAs that target genes found in CNV regions as well as the number of miRNA-binding sites are significantly higher than those of genes found in non-CNVregions.
“