linkstream2 microblog

What You Learn in Your #40s: there are no grown ups, 8hrs of… #sleep is one of life’s great pleasures…
http://www.nytimes.com/2014/03/01/opinion/sunday/what-you-learn-in-your-40s.html HT @haahr

by
P Druckerman
of Bebe fame

QT:{{”
The modern 40s are so busy it’s hard to assess them. Researchers describe the new “rush hour of life…”
….
Eight hours of continuous, unmedicated sleep is one of life’s great pleasures. Actually, scratch “unmedicated.”

There are no grown-ups. We suspect this when we are younger, but can confirm it only once we are the ones writing books and attending parent-teacher conferences. Everyone is winging it, some just do it more confidently.
…
Do not buy those too-small jeans, on the expectation that you will soon lose weight.
…
It’s O.K.if you don’t like jazz.
“}}

The Search for a Blockbuster Insomnia #Drug: from biochemical innovation to dosing gamesmanship (1/2)
http://www.newyorker.com/reporting/2013/12/09/131209fa_fact_parker MT @jekbradbury

.@jekbradbury Bizarre ending to story with $MRK arguing against efficacy of low-dose #suvorexant promoted by hyper-cautious FDA (2/2)

The night: Why they call it the graveyard shift. Health hazards of not #sleeping now treated like smoking in the ’50s
http://www.newscientist.com/article/mg22029450.700-the-night-why-they-call-it-the-graveyard-shift.html

Interesting discussion of a new sleep medication related to orexin, which is a protein that when removed is associated with narcolepsy.

http://stm.sciencemag.org/content/5/179/179ra44

Genome Res. 2001 Apr;11(4):531-9.
Identification and functional analysis of mutations in the hypocretin (orexin) genes of narcoleptic canines.
Hungs M, Fan J, Lin L, Lin X, Maki RA, Mignot E.
http://www.ncbi.nlm.nih.gov/pubmed/11282968

#Orexin Receptor Antagonists Differ from Standard #Sleep Drugs… Interesting discussion of a new insomnia medication
http://stm.sciencemag.org/content/5/179/179ra44

http://online.wsj.com/article/SB10000872396390444327204577615391893332580.html