Disorder in 3500 #proteomes from viruses and 3 domains of life http://www.tandfonline.com/doi/abs/10.1080/07391102.2012.675145 Larger human fraction of disordered residues (>40%)
Journal of Biomolecular Structure and Dynamics
Volume 30, Issue 2, 2012
DOI:10.1080/07391102.2012.675145B
Xue, A. Keith Dunker & Vladimir N. Uversky
pages 137-149
contains proteomics on some of the TCGA samples
http://proteomics.cancer.gov/programs/cptacnetwork
System-wide analyses have underestimated #protein abundances… Corrected protein conc. better correlated w/ #mRNA
https://peerj.com/articles/270
…once a non linear bias in mass spec. data is corrected, the concentration of the factor expressed at the median level is present at 70,000 molecules per cell. ….
Li, J, Bickel, P.J. and Biggin M.D. (2014) System Wide Analyses have Underestimated Protein Abundances and the Importance of Transcription in Mammals. PeerJ DOI10.7717/peerj.270
http://www.nature.com/msb/journal/v8/n1/pdf/msb201234.pdf
Quantitative measurement of allele-specific protein expression in a diploid yeast hybrid by LC-MS