linkstream2 microblog

an article describing the Think Tank was just published online in Genetics in Medicine:
http://www.nature.com/doifinder/10.1038/gim.2013.40

Paper giving a conceptual framework to somatic mosaicism

http://www.pnas.org/content/107/suppl.1/1725.full

http://www.nature.com/ng/journal/v45/n4/full/ng.2560.html?WT.ec_id=NG-201304

Adam D Ewing, Tracy J Ballinger, Dent Earl, Broad Institute Genome Sequencing and Analysis Program, Christopher C Harris, Li Ding, Richard K Wilson and David Haussler

http://genomebiology.com/2013/14/3/R22/abstract

Nat Biotechnol. 2012 May;30(5):413-21. doi: 10.1038/nbt.2203. Carter SL, Cibulskis K, Helman E, McKenna A, Shen H, Zack T, Laird PW, Onofrio RC, Winckler W, Weir BA, Beroukhim R, Pellman D, Levine DA, Lander ES, Meyerson M, Getz G.

pos. sel. from 1000G phase 1

http://www.cell.com/retrieve/pii/S0092867413000871
Cell, Volume 152, Issue 4, 703-713, 14 February 2013
Copyright © 2013 Elsevier Inc. All rights reserved.
10.1016/j.cell.2013.01.035
Sharon R. Grossman,Kristian G. Andersen,Ilya Shlyakhter,Shervin Tabrizi,Sarah Winnicki,Angela Yen,Daniel J. Park,Dustin
Griesemer,Elinor K. Karlsson,Sunny H. Wong,Moran Cabili,Richard A. Adegbola,Rameshwar N.K. Bamezai,Adrian V.S. Hill,Fredrik O.
Vannberg,John L. Rinn,1000 Genomes Project,Eric S. Lander,Stephen F. Schaffner,Pardis C. Sabeti

High-profile results challenged over statistical analysis of sequence data http://www.nature.com/news/rna-studies-under-fire-1.10502

“In July 2010, a team led by Catherine Dulac and Christopher Gregg, both then at Harvard University in Cambridge, Massachusetts, published a study in Science estimating that 1,300 mouse genes — an order of magnitude more than previously known — were imprinted.
Now, researchers are arguing that a flawed analysis led Dulac and Gregg to vastly over­estimate imprinting in their paper.”

http://www.nature.com/news/rna-studies-under-fire-1.10502

http://news.sciencemag.org/scienceinsider/2013/03/ready-for-more-10000-cancer-geno.html

https://www.cell.com/cancer-cell/abstract/S1535-6108(12)00520-X?switch=standard