Posts Tagged ‘folding’

PLOS Computational Biology: Catalysis of Protein Folding by Chaperones Accelerates Evolutionary Dynamics in Adapting Cell Populations

Friday, December 18th, 2015

Folding by Chaperones Accelerates Evolutionary Dynamics Multiscale models link NT mutations, PPIs & cell populations

The Protein-Folding Problem, 50 Years On

Saturday, November 23rd, 2013

Interesting discussion by Ken Dill reviewing the field of protein folding over the past 50 years. Dr Dill links it to a number of diseases such as Alzheimer’s, Parkinson’s and type II diabetes, which are transmitted by aberrantly folding proteins. There is also a bit of discussion about folding landscapes in the funnel.

The #Protein-Folding Problem, 50 Years On: Broad review, ranging from funnels to misfolded proteins & Alzheimer’s

Rare tRNAs driving protein folding paper

Thursday, September 26th, 2013

The gist is that it is important for protein folding to choose optimal and non-optimal synonymous codons, at different locations.

An interesting paper! Nice to see codon usage revisited again. Another revisiting of codons (my own) is at

Evolutionary conservation of codon optimality reveals hidden signatures of cotranslational folding
Sebastian Pechmann & Judith Frydman
Nature Structural & Molecular Biology 20, 237–243 (2013) doi:10.1038/nsmb.2466

Three-Dimensional Structures of Membrane Proteins from Genomic Sequencing

Friday, November 2nd, 2012